1-(2,2-dimethylhydrazide)-butanedioic acid; Succinic acid mono(2,2-dimethylhydrazide)
A highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC₅₀ values of 1.5, 0.55, and 2.1 μM, respectively. When tested for inhibition of other demethylase subfamily members (KDM3, KDM4, KDM5, KDM6) and other 2OG oxygenases (FIH, PHD2, BBOX1), daminozide was considerably less potent (IC₅₀’s > 100 μM).
Is it cell-permeable?
Is this a salt?
Protect from air and moisture
Maximum time for storage
DMSO (~15 mg/ml) or EtOH (~ 3 mg/ml) or H₂O (~ 15 mg/ml)
For cells, cell lines and tissues in culture till half confluency.