BCMA (TNFRSF17) Antibody
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Catalog number3577-100
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PricePlease ask
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Size100 µg
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Antibody TargetBCMA (TNFRSF17)
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Target Alternative NameB Cell Maturation, BCM, CD269, TNFRSF17, 109545, Q02223, BCMA
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Antibody TypePolyclonal
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Species ReactivitiesMouse, Rat
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Immunogen SequenceSynthetic peptide of human BCMA at C-terminal
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AccessionQ02223
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Gene Id608
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AppearanceColorless liquid
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FormLiquid
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Concentration0.5 mg/ml
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Formulation100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
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PurificationAffinity purified rabbit IgG
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ApplicationWestern blot
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Positive ControlWestern blot:mouse muscle lysate, rat kidney lysate,K562 lysate,U937 lysate
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Application And UsagesWestern blot: 1-4 µg
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DescriptionBCMA, also named TNFRSF17, is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-κ-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is involved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-κB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells.
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Dot Blot VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolTNFRSF17
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Short nameBCMA (TNFRSF17) Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Isotyperabbit IgG
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Alternative nameBCMA (tumor necrosis factor receptor superfamily, member 17) (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targettumor necrosis factor receptor superfamily, member 17, BCM and BCMA and CD269 and TNFRSF13A, TNFRSF17 and IDBG-15042 and ENSG00000048462 and 608, tumor necrosis factor-activated receptor activity, Plasma membranes, Tnfrsf17 and IDBG-133357 and ENSMUSG00000022496 and 21935
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Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 17
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 17
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-11-20
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Entrez gene record
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Pubmed identfication
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Classification
- CD molecules
- Tumor necrosis factor receptor superfamily
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
