anti- AKR1C3 antibody

• Catalog number
  FNab00262
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
• Immunogen
  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
• Synonyms
  17 beta HSD 5, 3 alpha HSD type 2, 3 alpha HSD type II, brain, AKR1C3, DD 3, DD3, DDX, Dihydrodiol dehydrogenase 3, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, Indanol dehydrogenase, KIAA0119, PGFS, Prostaglandin F synthase
• Calculated MW
  Refer to figures
• Uniprot ID
  P42330
• Specificity
  Human, Rat
• Tested Application
  ELISA, WB, IHC, IF
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
• Image1
  Immunohistochemistry of paraffin-embedded human breast cancer using FNab00262(AKR1C3 antibody) at dilution of 1:100
• Image4
  HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00262(AKR1C3 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  AKR1C3  
• Gene symbol
  AKR1C3
• Short name
  anti- AKR1C3 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- aldo-keto reductase family 1, member complement component 3 (3-a hydroxysteroid dehydrogenase, classification II) (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), DD3 and DDX and HA1753 and HAKRB and HAKRe and hluPGFS and HSD17B5 and PGFS, AKR1C3 and IDBG-47964 and ENSG00000196139 and 8644, oxidoreductase activity, nuclei

Gene info

• Identity
  HGNC:386
• Gene
  AKR1C3
• Long gene name
  aldo-keto reductase family 1 member C3
• Synonyms gene
  • HSD17B5
• Synonyms gene name
  • hydroxysteroid (17-beta) dehydrogenase 5
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
• Synonyms
  • KIAA0119
  • DDX
  • HAKRB
  • PGFS
• Synonyms name
  • dihydrodiol dehydrogenase X
  • prostaglandin F synthase
  • 3-alpha hydroxysteroid dehydrogenase, type II
• GenBank acession
  • L43839
• Locus
  10p15.1
• Discovery year
  1998-09-29
• Entrez gene record
  8644
• Pubmed identfication
  • 7650035
  • 9792917
• RefSeq identity
  • NM_003739
• Classification
  • Aldo-keto reductases
• VEGA ID
  OTTHUMG00000017585

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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