Human CellExp™ SARS-CoV-2 S1 Protein (D614G), Recombinant
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Catalog numberP1652-50
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PricePlease ask
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Size50 µg
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SynonymsSARS-CoV-2 S1 Protein (D614G), Recombinant,SARS-CoV-2 S1 Protein (D614G),SARS-CoV-2 S1 (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G), Recombinant,S1 Protein (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G),Human CellExp™ SARS-CoV-2 S1 Protein (D614G),S1 (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G)
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Alternative_namesSARS-CoV-2 S1 Protein (D614G), Recombinant,SARS-CoV-2 S1 Protein (D614G),SARS-CoV-2 S1 (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G), Recombinant,S1 Protein (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G),Human CellExp™ SARS-CoV-2 S1 Protein (D614G),S1 (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G)
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DescriptionRecombinant SARS-CoV-2 S1 spike protein with a mutation (D614G)
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Recombinant1
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SourceHEK 293 cells
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Purity by SDS PAGE> 95% SDS-PAGE
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Molecular Weight120 kDa
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Storage Temp-20ºC
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ShippingGel Pack
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Shelf Life12 months
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ConcentrationLot dependent
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AppearanceLyophilized powder
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Reconstitution InstructionsCentrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
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Background InformationSARS-CoV-2, the causative virus of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The virus uses multiple factors including the human protease Furin, Angiotensin converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and the transmembrane protease serine 2 (TMPRSS2) for receptor interactions. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives the membrane fusion and eventual entry of the virus. The S glycoprotein serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. Within the S1 protein, the conserved receptor-binding domain (RBD) binds with a high affinity for ACE2. Recently, a new strain of SARS-CoV-2 has been discovered with a mutation in the S1 protein (amino acid D614 to G614) outside the RBD. Early studies provide evidence that D614G SARS-CoV-2 virus strain is likely to be more infectious and is present in the majority of current infections globally.
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Amino acid sequenceVal 16 - Arg 685
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolSARS1, SARS2
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Short nameCellExp™ SARS-CoV-2 S1 Protein (D614G), Recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHumans
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Alternative nameH. sapiens CellExp™ SARS-CoV-2 S1 Protein (D614G), Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameseryl-tRNA synthetase 1
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Synonyms gene
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Synonyms gene name
- seryl-tRNA synthetase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-06-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Aminoacyl tRNA synthetases, Class II
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameseryl-tRNA synthetase 2, mitochondrial
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Synonyms gene
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Synonyms gene name
- serine-tRNA ligase, mitochondrial
- seryl-tRNA synthetase 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-10-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Aminoacyl tRNA synthetases, Class II
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data