IKK beta Antibody (phospho-S689)

• Catalog number
  F48703-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  IKK beta (phospho-S689)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  DB, ELISA
• Recommended dilutions
  Dot blot: 1:500
• Notes
  Titration of the phospho-IKKB antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This phospho-IKKB antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O14920
• Purity
  Antigen affinity
• Description
  NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
• Immunogen
  This phospho-IKKB antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS689 of human IKKB.
• Storage
  Aliquot the phospho-IKKB antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  IKK   beta   phospho-S689  
• Gene symbol
  IKBKE, IKBKB, CHUK, IKBKG
• Short name
  Anti-IKK beta (phospho-S689)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to IKK beta (phospho-S689)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:14552
• Gene
  IKBKE
• Long gene name
  inhibitor of nuclear factor kappa B kinase subunit epsilon
• Synonyms gene name
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
• Synonyms
  • IKKE
  • IKK-i
  • KIAA0151
• GenBank acession
  • AB016590
• Locus
  1q32.1
• Discovery year
  2002-12-02
• Entrez gene record
  9641
• Pubmed identfication
  • 10421793
  • 10882136
• Classification
  • I kappa B kinases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000184613

Gene info

• Identity
  HGNC:5960
• Gene
  IKBKB
• Long gene name
  inhibitor of nuclear factor kappa B kinase subunit beta
• Synonyms gene name
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
• Synonyms
  • IKK2
  • NFKBIKB
  • IKK-beta
  • IKKB
• GenBank acession
  • AF029684
• Locus
  8p11.21
• Discovery year
  1998-02-11
• Entrez gene record
  3551
• Pubmed identfication
  • 9878263
  • 9763654
  • 18308615
• Classification
  • I kappa B kinases
  • IKK complex
• VEGA ID
  OTTHUMG00000164092
• Locus Specific Databases
  • LRG_1241

Gene info

• Identity
  HGNC:1974
• Gene
  CHUK
• Long gene name
  component of inhibitor of nuclear factor kappa B kinase complex
• Synonyms gene
  • TCF16
• Synonyms gene name
  • conserved helix-loop-helix ubiquitous kinase
• Synonyms
  • IKK1
  • IKK-alpha
  • IkBKA
  • NFKBIKA
  • IKKA
• Synonyms name
  • inhibitor of nuclear factor kappa-B kinase subunit alpha
  • I-kappa-B kinase
• GenBank acession
  • AF009225
• Locus
  10q24.31
• Discovery year
  1995-03-15
• Entrez gene record
  1147
• Pubmed identfication
  • 7558004
  • 16902410
• RefSeq identity
  • NM_001278
• Classification
  • I kappa B kinases
  • IKK complex
• VEGA ID
  OTTHUMG00000018899

Gene info

• Identity
  HGNC:5961
• Gene
  IKBKG
• Long gene name
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
• Synonyms gene
  • IP2
  • IP1
• Synonyms gene name
  • incontinentia pigmenti
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • inhibitor of nuclear factor kappa B kinase subunit gamma
• Synonyms
  • IKK-gamma
  • NEMO
  • Fip3p
  • FIP-3
  • FIP3
  • ZC2HC9
  • IKKAP1
  • IKKG
• Synonyms name
  • NF-kappa-B essential modulator
  • IkB kinase-associated protein 1
  • I-kappa-B kinase subunit gamma
  • IkB kinase subunit gamma
  • 14.7K (adenovirus E3 protein) interacting protein 3
• GenBank acession
  • AF074382
• Locus
  Xq28
• Discovery year
  1998-09-30
• Entrez gene record
  8517
• Pubmed identfication
  • 9751060
  • 10087442
  • 11590134
  • 11242109
• RefSeq identity
  • NM_003639
• Classification
  • Zinc fingers C2HC-type
  • IKK complex
• VEGA ID
  OTTHUMG00000024234
• Locus Specific Databases
  • IKBKGbase: Mutation registry for Nemo deficiency
  • Global Variome shared LOVD
  • LRG_70

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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