IL-2R gamma Antibody, ALEXA FLUOR 350
-
Catalog numberbs-2545R-A350
-
PricePlease ask
-
Size100ul
-
-
Long nameIL-2R gamma Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
-
Also known asAnti-IL-2R gamma PAb ALEXA FLUOR 350
-
CategoryConjugated Primary Antibodies
-
Conjugated withALEXA FLUOR® 350
-
Host OrganismRabbit (Oryctolagus cuniculus)
-
Target AntigenIL-2R gamma
-
SpecificityThis is a highly specific antibody against IL-2R gamma.
-
ModificationUnmodified
-
Modification SiteNone
-
ClonalityPolyclonal
-
ClonePolyclonal antibody
-
Concentration1ug per 1ul
-
Immunogen range135-185/369
-
Subcellular locationExtracellular
-
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human IL-2R gamma
-
Gene ID Number3561
-
Swiss ProtP31785
-
Tested applicationsIF(IHC-P)
-
Recommended dilutionsIF(IHC-P)(1:50-200)
-
CrossreactivityHuman, Mouse, Rat
-
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the antigenInterleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement.
-
PurificationPurified by Protein A.
-
Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
-
Excitation emission343nm/442nm
-
SynonymsP64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1; Cytokine receptor common subunit gamma; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; gammaC; IL2RG
-
PropertiesFor facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
ConjugationAlexa Fluor, ALEXA FLUOR 350
-
French translationanticorps
-
Gene target
-
Gene symbolVCX2, IL2RA, IL36G, IL25, IL22, IL18, IL37, IL6R, IL17C, IL17A
-
Short nameAnti-IL-2R gamma
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
IsotypeImmunoglobulin G (IgG)
-
LabelALEXA FLUOR 350
-
Alternative nameIL-2R gamma Polyclonal Antibody, ALEXA FLUOR 350
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namevariable charge X-linked 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2004-04-16
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Variable charge X/Y family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 2 receptor subunit alpha
-
Synonyms gene
-
Synonyms gene name
- insulin-dependent diabetes mellitus 10
- interleukin 2 receptor, alpha
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1990-01-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
- Sushi domain containing
- Interleukin receptors
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 36 gamma
-
Synonyms gene
-
Synonyms gene name
- interleukin 1 family, member 9
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-08-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 25
-
Synonyms gene
-
Synonyms gene name
- interleukin 17E
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2001-01-26
-
Pubmed identfication
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 22
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-03-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 18
-
Synonyms gene name
- interleukin 18 (interferon-gamma-inducing factor)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1997-07-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 37
-
Synonyms gene
-
Synonyms gene name
- interleukin 1 family, member 7 (zeta)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-08-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 6 receptor
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
- Interleukin receptors
- Immunoglobulin like domain containing
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 17C
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2000-01-20
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 17A
-
Synonyms gene
-
Synonyms gene name
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1993-10-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data