Human CellExp™ NOV, human recombinant

• Catalog number
  P1022-25
• Price
  Please ask
• Size
  25 µg

• Synonyms
  Nephroblastoma Overexpressed gene, CCN3, IGFBP9, NovH
• Alternative_names
  Nephroblastoma Overexpressed gene, CCN3, IGFBP9, NovH
• Recombinant
  Yes
• Source
  CHO cells
• Purity by SDS PAGE
  > 95%
• Assay
  SDS-PAGE
• Purity
  > 95%
• Endotoxin Level
  < 0.2 EU/ug
• Activity Specifications test method
  Prolifiration assay
• Biological activity
  ED50
• Molecular Weight
  20-50 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized after extensive dialysis against PBS.
• Reconstitution Instructions
  Reconstituted in ddH2O at 100 ug/mL.
• Background Information
  Nephroblastoma Overexpressed Gene Protein (NOV), also known as CCN3, IGFBP9 and NOVH, is one of the CCN family of secreted proteins. It is expressed in bone marrow, thymic cells and nephroblastoma. NOV signals through integrin receptors, NOTCH1 and fibulin 1c to regulate multiple cellular activities, such as cell adhesion, migration, proliferation and differentiation. The reported functions of NOV are diverse. It has been reported to play a role in angiogenesis and stem cell self-renewal. It has also been implicated in osteogenic differentiation, embryo development and cancer pathogenesis.
• Amino acid sequence
  TQRCPPQCPG RCPATPPTCA PGVRAVLDGC SCCLVCARQR GESCSDLEPC DESSGLYCDR SADPSNQTGI CTAVEGDNCV FDGVIYRSGE KFQPSCKFQC TCRDGQIGCV PRCQLDVLLP EPNCPAPRKV EVPGECCEKW ICGPDEEDSL GGLTLAAYRP EATLGVEVSD SSVNCIEQTT EWTACSKSCG MGFSTRVTNR NRQCEMLKQT RLCMVRPCEQ EPEQPTDKKG KKCLRTKKSL KAIHLQFKNC TSLHTYKPRF CGVCSDGRCC TPHNTKTIQA EFQCSPGQIV KKPVMVIGTC TCHTNCPKNN EAFLQELELK TTRGKM
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   NOV  
• Gene symbol
  CCN3, PLXNA1, RPL10
• Short name
  CellExp™ NOV, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ NOV, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:7885
• Gene
  CCN3
• Long gene name
  cellular communication network factor 3
• Synonyms gene
  • NOV
• Synonyms gene name
  • nephroblastoma overexpressed gene
  • nephroblastoma overexpressed
• Synonyms
  • IGFBP9
• GenBank acession
  • X96584
• Locus
  8q24.12
• Discovery year
  1993-11-05
• Entrez gene record
  4856
• Pubmed identfication
  • 1334251
• RefSeq identity
  • NM_002514
• Classification
  • Cellular communication network factors
• VEGA ID
  OTTHUMG00000164984

Gene info

• Identity
  HGNC:9099
• Gene
  PLXNA1
• Long gene name
  plexin A1
• Synonyms gene
  • PLXN1
• Synonyms
  • NOV
• GenBank acession
  • X87832
• Locus
  3q21.3
• Discovery year
  1998-08-13
• Entrez gene record
  5361
• Pubmed identfication
  • 8570614
• RefSeq identity
  • NM_032242
• Classification
  • Plexins
  • IPT domain containing
• VEGA ID
  OTTHUMG00000044222

Gene info

• Identity
  HGNC:10298
• Gene
  RPL10
• Long gene name
  ribosomal protein L10
• Synonyms
  • NOV
  • QM
  • DXS648E
  • DXS648
  • FLJ23544
  • L10
• GenBank acession
  • AB007170
• Locus
  Xq28
• Discovery year
  1998-07-23
• Entrez gene record
  6134
• Pubmed identfication
  • 9582194
• RefSeq identity
  • NM_006013
• Classification
  • Small nucleolar RNA protein coding host genes
  • L ribosomal proteins
• VEGA ID
  OTTHUMG00000033189
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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