ADX-47273

Alternative_name

(S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone
Description

ADX-47273 is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC₅₀ = 0.17 μm, with no effect on other mGluR subtypes. ADX-47273 elevates extracellular signal-regulated kinase and cAMP-responsive element-binding protein phosphorylation in hippocampus and prefrontal cortex.
CAS Number

851881-60-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₁₇F₂N₃O₂
Molecular Weight

369.37
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>30 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective mGluR5 receptor PAM (positive allosteric modulator)
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

11383075
PubChem CID Link
SMILES

C1CC(CN(C1)C(=O)C2=CC=C(C=C2)F)C3=NC(=NO3)C4=CC=C(C=C4)F
InChi

InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1
InChi Key

VXQCCZHCFBHTTD-HNNXBMFYSA-N
Data Sheet Link
MSDS Available

Yes