IM-12 is a potent and selective GSK-3β inhibitor (IC₅₀ = 53 nM). It significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling.
Yellow orange solid
Is this a salt?
Is it cell-permeable?
≥98% by HPLC
DMSO (25 mg/ml) or EtOH (5 mg/ml)
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
IM-12 for activation
IM-12 to measure cellular activation