anti- alpha Actinin antibody
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Catalog number
FNab00322
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Price
Please ask
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Size
2X100μg
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Form
liquid
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Purification
Immunogen affinity purified
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Purity
≥95% as determined by SDS-PAGE
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Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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Background
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
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Immunogen
actinin, alpha 1
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Synonyms
actinin, alpha 1, ACTN1, alpha Actinin, Alpha actinin 1, F actin cross linking protein, Non muscle alpha actinin 1
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Calculated MW
110 kDa
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Uniprot ID
P12814
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Specificity
Human, Mouse, Monkey
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Tested Application
ELISA, WB, IHC
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Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
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Image1
Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab00322( a-Actinin Antibody) at dilution of 1:200
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Image4
NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab00322( a-Actinin Antibody) at dilution of 1:1000
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Description
The anti- alpha Actinin antibody is a α- or alpha protein sometimes glycoprotein present in blood. This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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Properties
If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ACTN3, ACTN1, ACTN2
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Short name
anti- alpha Actinin antibody
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Technique
Antibody, anti, antibody to, antibodies against human proteins, antibodies for
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Host
Rabbit
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Isotype
IgG
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Alternative name
antibody to- a Actinin (antibody to-)
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
actinin alpha 3
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Synonyms gene name
- actinin, alpha 3
- actinin alpha 3 (gene/pseudogene)
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GenBank acession
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Locus
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Discovery year
1991-07-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
actinin alpha 1
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GenBank acession
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Locus
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Discovery year
1990-08-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene name
actinin alpha 2
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GenBank acession
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Locus
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Discovery year
1991-07-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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