Akt Inhibitor, Isozyme-Selective

• Catalog number
  1708-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2
• Description
  Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC₅₀ = 58 nM (Akt1), 210 nM (Akt2) and 2.12 µM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 µM).
• CAS Number
  612847-09-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₄H₂₉N₇O
• Molecular Weight
  551.65
• Cell Permeable
  Yes
• Purity
  ≥97% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and moisture
• Tag Line
  An Akt inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD08705407
• PubChem CID
  10196499
• PubChem CID Link
• SMILES
  C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7
• InChi
  InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)
• InChi Key
  BIWGYFZAEWGBAL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Akt   Inhibitor   Isozyme-Selective  
• Short name
  Akt Inhibitor, Isozyme-Selective
• Alternative name
  Akt suppressor, Isozyme-Selective

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