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Gene info
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
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Gene names
ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl, BHLHE39, Abelson murine leukemia viral oncogene homolog 1
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Antibodie s label
unlabelled serum
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Purity
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
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Ab raised in
Rabbit
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Type
Polyclonal
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Spicific to
This antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429.
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Antigen
ABL1/2 (phospho-Tyr393/429) antibody was made against a peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y (p) -T-A) derived from Human ABL1/2.
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Immuno application
Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody advice
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
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Suspention pH azide
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Keep at
Store antibody at -20 grades C for up to one year.
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Works with
Human, Mouse
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Omim nr
62362414 / 209862772
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Ncbi nr
NP_005148.2 / NP_001129472.1
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KDa
210 kDa
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
25 / 27
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GENE symbol
ABL1 ABL2
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Antigene name
c-abl oncogene 1, non-receptor tyrosine kinase / c-abl oncogene 2, non-receptor tyrosine kinase
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Source
Homo sapiens
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Protein nr
P00519 P42684
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ABL1
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Short name
anti-ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toABL1 / 2 (phosphorilated Tyr393 / Tyr429) (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
c-abl oncogene 1, non-receptor tyrosine kinase, ABL and bcr/abl and c-ABL and c-ABL1 and JTK7 and p150 and v-abl, ABL1 and IDBG-89599 and ENSG00000097007 and 25, transferase activity, nuclei, Abl1 and IDBG-158216 and ENSMUSG00000026842 and 11350, ABL1 and IDBG-639939 and ENSBTAG00000017976 and 540876
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