Rabbit Anti Human AIRE Antibody-Non-conjugated

• Catalog number
  CSB-PA001502HA01HU_100ug
• Price
  Please ask
• Size
  100ug

• Long name
  Rabbit Antibody against Human AIRE, Non-conjugated
• Synonym name
  AIRE Human Antibody
• Species reactivity
  Human
• Tested applications recommended dilutions
  ELISA,IHC,IF;Recommended dilution:IHC:1:20-1:200,IF:1:50-1:200
• Conjugation
  Non-conjugated
• Antibody isotype
  IgG
• UniProt ID
  O43918
• Format
  Liquid, diluted in buffer
• Buffer composition
  Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Purity
  >95%
• Purification method
  Protein G purified
• Antibody category
  Polyclonal Antibodies
• Immunogen type
  Recombinant human Autoimmune regulator protein (39-108AA)
• Immunogen species
  Human
• Alias
  Autoimmune regulator,Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein,APECED protein,AIRE,APECED
• Background
  Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
• Clonality
  Polyclonal antibody
• Shipping and storage
  AIRE Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
• Short name of the antigen
  Autoimmune regulator
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  AIRE   Non-conjugated  
• Gene symbol
  AIRE
• Short name
  Anti-AIRE
• Technique
  anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
• Host
  Rabbit, Rabbits
• Species
  Human, Humans
• Alternative name
  AIRE Antibody
• Alternative technique
  antibodies, rabbit-anti
• Alternative to gene target
  autoimmune regulator, AIRE1 and APECED and APS1 and APSI and PGA1, AIRE and IDBG-5152 and ENSG00000160224 and 326, translation regulator activity, nuclei, Aire and IDBG-168233 and ENSMUSG00000000731 and 11634, AIRE and IDBG-639674 and ENSBTAG00000023393 and

Gene info

• Identity
  HGNC:360
• Gene
  AIRE
• Long gene name
  autoimmune regulator
• Synonyms gene
  • APECED
• Synonyms gene name
  • autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
• Synonyms
  • PGA1
  • APS1
• Synonyms name
  • autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
• GenBank acession
  • AB006684
• Locus
  21q22.3
• Discovery year
  1997-09-05
• Entrez gene record
  326
• Pubmed identfication
  • 9398840
• Classification
  • PHD finger proteins
• VEGA ID
  OTTHUMG00000086921
• Locus Specific Databases
  • AIREbase: Mutation registry for APECED
  • LRG_18

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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