GSK-199 hydrochloride

  • Catalog number
    B1037-500
  • Price
    Please ask
  • Size
    500 ug
  • Alternative_name
    (R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
  • Description
    GSK-199 is a potent, reversible inhibitor of PAD4 (IC₅₀ = 200 nM. It binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3. It is less potent than the related PAD4 inhibitor GSK484 (IC₅₀ = 50 nM). GSK-199 can inhibit the citrullination of PAD4 target proteins and diminish the formation of neutrophil extracellular traps in mouse neutrophils.
  • CAS Number
    1549811-53-1
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₄H₂₉ClN₆O₂
  • Molecular Weight
    468.98
  • Cell Permeable
    Yes
  • Purity
    ≥98%
  • Solubilities
    DMSO (~30 mg/ml)
  • Handling
    Protect from air and moisture
  • Tag Line
    A potent, reversible inhibitor of PAD4
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • SMILES
    O=C(N1C[C@H](N)CCC1)C2=CC(OC)=C3N(C)C(C4=CC5=CC=CN=C5N4CC)=NC3=C2.[H]Cl
  • InChi
    InChI=1S/C24H28N6O2.ClH/c1-4-30-19(12-15-7-5-9-26-22(15)30)23-27-18-11-16(13-20(32-3)21(18)28(23)2)24(31)29-10-6-8-17(25)14-29;/h5,7,9,11-13,17H,4,6,8,10,14,25H2,1-3H3;1H/t17-;/m1./s1
  • InChi Key
    KRGMIOKDGHBYQE-UNTBIKODSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    OR5M11
  • Short name
    GSK-199 hydrochloride
  • Alternative name
    GSK-199 hydrochloride
Gene info
  • Identity
  • Gene
  • Long gene name
    olfactory receptor family 5 subfamily M member 11
  • Synonyms gene name
    • olfactory receptor, family 5, subfamily M, member 11
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-03-28
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Olfactory receptors, family 5
  • VEGA ID
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