AS 041164 , PI 3-Kgamma kinase inhibitor

  • Catalog number
    SIH-433-10MG
  • Price
    Please ask
  • Size
    10 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    6318-41-8
  • Description
    PI 3-Kgamma kinase inhibitor
  • Molecular weight
    249,2 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    NSC31098, 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C11H7NO4S
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (TLC)
  • Soluble in
    Soluble in DMSO (25 mg/ml). For in vivo administration this compound was suspended in 0.5% carboxymethylcellulose/0.25% Tween 20 as a vehicle
  • Physical appearance
    Yellow solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    233033
  • Scientific context
    AS 041164 is a selective PI 3-Kγ isoform inhibitor. It also blocks neutrophil migration.
  • Bibliography
    1. Ferrandi C., et al. (2007) J. Pharmacol. Exp.Ther. 322(3): 923–930.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of AS 041164 (SIH-433), a PI 3-Kgamma kinase inhibitor. CAS #: 6318-41-8. Molecular Formula: C11H7NO4S. Molecular Weight: 249.2 g/mol. Chemical structure of AS 041164 , a PI 3-Kgamma kinase inhibitor (SIH-433). CAS # 6318-41-8. Molecular Formula: C11H7NO4S.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.01
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    AS 041164 , PI 3-Kgamma kinase inhibitor
  • Alternative name
    AS 041164 , PI 3-Kgamma phosphorylation catalyst suppressor
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