TGF beta 1 Antibody

• Catalog number
  bs-4908R
• Price
  Please ask
• Size
  0.1ml

• Long name
  TGF beta 1 Primary Polyclonal Antibody
• Also known as
  TGF beta 1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  TGF beta 1
• Specificity
  This is a highly specific antibody against TGF beta 1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  100-150/390
• Subcellular location
  Secreted
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TGF beta 1/LAP
• Gene ID number
  7040
• Swiss Prot
  P01137
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CED; LAP; DPD1; TGFB; TGFbeta; Transforming growth factor beta-1; TGF-beta-1; TGFB1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TGF   beta  
• Gene symbol
  LTBP1, TAB3, TAB3P1
• Short name
  Anti-TGF beta 1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  TGF beta 1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6714
• Gene
  LTBP1
• Long gene name
  latent transforming growth factor beta binding protein 1
• Synonyms name
  • TGF-beta1-BP-1
• Locus
  2p22.3
• Discovery year
  1993-09-20
• Entrez gene record
  4052
• Pubmed identfication
  • 2350783
  • 11104663
• RefSeq identity
  • NM_206943
• Classification
  • Latent transforming growth factor beta binding proteins
• VEGA ID
  OTTHUMG00000152118

Gene info

• Identity
  HGNC:30681
• Gene
  TAB3
• Long gene name
  TGF-beta activated kinase 1 (MAP3K7) binding protein 3
• Synonyms gene
  • MAP3K7IP3
• Synonyms gene name
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 3
  • TGF-beta activated kinase 1/MAP3K7 binding protein 3
  • TGF-beta activated kinase 1 and MAP3K7 binding protein 3
• Synonyms name
  • TAK1 binding protein 3
• GenBank acession
  • AY331591
• Locus
  Xp21.2
• Discovery year
  2006-06-26
• Entrez gene record
  257397
• Pubmed identfication
  • 14633987
  • 14670075
• RefSeq identity
  • NM_152787
• Classification
  • Zinc fingers RANBP2-type
• VEGA ID
  OTTHUMG00000021329
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:37723
• Gene
  TAB3P1
• Long gene name
  TGF-beta activated kinase 1/MAP3K7 binding protein 3 pseudogene 1
• Locus
  Yq11.221
• Discovery year
  2010-02-05
• Entrez gene record
  643199
• VEGA ID
  OTTHUMG00000036321

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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