IRAK4 Antibody

• Catalog number
  bs-50510R
• Price
  Please ask
• Size
  0.1ml

• Long name
  IRAK4 Primary Polyclonal Antibody
• Also known as
  IRAK4 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  IRAK4
• Specificity
  This is a highly specific antibody against IRAK4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  Synthetic peptide
• Swiss Prot
  Q8TDF7
• Tested Applications
  WB
• Recommended dilutions
  WB (0.5 ug/ml)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  IL-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. All TIRs with known function are involved in host defense mechanisms, either by the recognition of pathogens or as receptors for proinflammatory cytokines. They play a crucial role in the switch from innate to adaptive immunity in mammals, and the signaling cascades initiated by these receptors are implicated in a number of human diseases. To date, four IRAK genes have been identified in the human genome, namely IRAK1, IRAK2, IRAK-M and IRAK4. Each distinct IRAK may have highly specific downstream target, and therefore, contribute to the specific activation of cellular response upon distinct TLR ligand challenge, such as signaling pathways leading to cellular apoptosis (IRAK2), NF-κB activation and inflammatory cytokine expression (IRAK4 and 2), Stat3 activation and IL-10 expression (IRAK1), and inhibition of NF-κB activation (IRAK-M).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  IRAK4  
• Gene symbol
  IRAK4
• Short name
  Anti-IRAK4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  IRAK4 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  interleukin-1 receptor-associated kinase 4, IRAK4 and IDBG-28022 and ENSG00000198001 and 51135, transferase activity, Extracellular, Irak4 and IDBG-177236 and ENSMUSG00000059883 and 266632, IRAK4 and IDBG-633310 and ENSBTAG00000021105 and 533692

Gene info

• Identity
  HGNC:17967
• Gene
  IRAK4
• Long gene name
  interleukin 1 receptor associated kinase 4
• Synonyms
  • NY-REN-64
• GenBank acession
  • AF155118
• Locus
  12q12
• Discovery year
  2002-09-27
• Entrez gene record
  51135
• Pubmed identfication
  • 3772297
  • 10508479
• VEGA ID
  OTTHUMG00000169425
• Locus Specific Databases
  • IRAK4base: Mutation registry for IRAK4 deficiency
  • LRG_75

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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