GNE-3511

Alternative_name

2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Description

GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.
CAS Number

1496581-76-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C23H26F2N6O
Molecular Weight

440.49
Cell Permeable

Yes
Purity

>98% by HPLC
Solubilities

DMSO ≥ 32 mg/ml
Handling

Protect from air and light
Tag Line

A potent and selective zipper kinase (DLK, MAP3K12) inhibitors.
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

72547959
PubChem CID Link
SMILES

C1CN(CCC1C2=CC(=NC(=C2)NC3=NC=CC(=C3)C#N)N4CCC(C4)(F)F)C5COC5
InChi

1S/C23H26F2N6O/c24-23(25)4-8-31(15-23)22-11-18(17-2-6-30(7-3-17)19-13-32-14-19)10-21(29-22)28-20-9-16(12-26)1-5-27-20/h1,5,9-11,17,19H,2-4,6-8,13-15H2,(H,27,28,29)
InChi Key

RHFIAUKMKYHHFA-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

GNE-3511
Gene symbol

GNE
Short name

GNE-3511
Alternative name

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase-3511
Alternative to gene target

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, DMRV and GLCNE and IBM2 and NM and Uae1, GNE and IDBG-65042 and ENSG00000159921 and 10020, hydrolase activity, Cytoplasm, Gne and IDBG-143173 and ENSMUSG00000028479 and 50798, GNE and IDBG-633656 and ENSBTAG00000001142 and 782201

Identity

HGNC:23657
Gene

GNE
Long gene name

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms gene
- IBM2
Synonyms gene name
- UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
Synonyms
- Uae1
Synonyms name
- bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
GenBank acession
- AF051852
Locus

9p13.3
Discovery year

2003-11-28
Entrez gene record

10020
Pubmed identfication
- 9305887
- 9305888
RefSeq identity
- NM_005476
VEGA ID

OTTHUMG00000019899
Locus Specific Databases
- LRG_1197