Caspase-12 Inhibitor Z-ATAD-FMK

• Catalog number
  1079-20C
• Price
  Please ask
• Size
  20 ul (10 mM)

• Alternative_name
  Z-ATAD-FMK, Caspase-12 Inhibitor, Z-ATAD-fluoromethylketone
• Description
  A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
• Structure Available
  No
• Peptide sequence
  Z-Ala-Thr-Ala-Asp(OMe)-FMK
• Salt Form
  No
• Molecular Formula
  C₂₄H₃₃N₄O₉F
• Molecular Weight
  540.54
• Cell Permeable
  Yes
• Purity
  >95% by HPLC
• Handling
  Protect from light and moisture
• Tag Line
  A caspase-12 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• SMILES
  N/A
• InChi
  N/A
• InChi Key
  N/A
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Caspase-12   Inhibitor   Z-ATAD-FMK  
• Gene symbol
  PSMB7, PLA2G4F, HLA-Z, ZNF276
• Short name
  Caspase-12 Inhibitor Z-ATAD-FMK
• Alternative name
  caspase-12 suppressor Z-ATAD-FMK

Gene info

• Identity
  HGNC:9544
• Gene
  PSMB7
• Long gene name
  proteasome 20S subunit beta 7
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, beta type, 7
  • proteasome subunit beta 7
• Synonyms
  • Z
• Synonyms name
  • proteasome subunit β2
• GenBank acession
  • AJ420455
• Locus
  9q33.3
• Discovery year
  1995-11-22
• Entrez gene record
  5695
• Pubmed identfication
  • 8811196
• RefSeq identity
  • NM_002799
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000021042

Gene info

• Identity
  HGNC:27396
• Gene
  PLA2G4F
• Long gene name
  phospholipase A2 group IVF
• Synonyms gene name
  • phospholipase A2, group IVF
• Synonyms
  • PLA2G4F/Z
• Locus
  15q15.1
• Discovery year
  2005-11-04
• Entrez gene record
  255189
• Pubmed identfication
  • 14702039
  • 15866882
• RefSeq identity
  • NM_213600
• Classification
  • C2 domain containing phospholipases
  • Phospholipases
• VEGA ID
  OTTHUMG00000172782

Gene info

• Identity
  HGNC:19394
• Gene
  HLA-Z
• Long gene name
  major histocompatibility complex, class I, Z (pseudogene)
• Synonyms
  • HLA-Z1
• Locus
  6p21.32
• Discovery year
  2002-10-23
• Entrez gene record
  267017
• Pubmed identfication
  • 8568858
• RefSeq identity
  • NG_009944
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031189
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:23330
• Gene
  ZNF276
• Long gene name
  zinc finger protein 276
• Synonyms gene
  • ZFP276
• Synonyms gene name
  • zinc finger protein 276 homolog (mouse)
• Synonyms
  • MGC45417
  • ZNF477
  • CENPZ
  • CENP-Z
  • ZADT
• Synonyms name
  • centromere protein Z
  • zinc finger, AD-type
• GenBank acession
  • AK026482
• Locus
  16q24.3
• Discovery year
  2003-11-07
• Entrez gene record
  92822
• Pubmed identfication
  • 10936049
  • 20813266
• RefSeq identity
  • NM_152287
• Classification
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000138050

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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