This antibody has been succesfully tested for use in following methods:
Western blot, IHC, FACS.
Target of this antibody:
Formulation of this antibody:
In PBS with 0.09% (W/V) sodium azide.
Alternative names of antibody target:
BMPR2; PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II
WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.
Shelf time: 12 months in temp.: -20 deg.C
This antibody reacts with:
Clonality of antibody:
Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.
How to handle this antibody:
The antibody solution should be gently mixed before use.
BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis. In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury.
Form of antibody:
Concentration of antibody:
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
anti-BMPR2 Antibody (NT)
antibody to-bone morphogenetic protein receptor, classification II (serine/threonine kinase) (Antibody to) (NT)
Alternative to gene target
bone morphogenetic protein receptor, type II (serine/threonine kinase), BMPR-II and BMPR3 and BMR2 and BRK-3 and POVD1 and PPH1 and T-ALK, BMPR2 and IDBG-78880 and ENSG00000204217 and 659, activin receptor activity, Extracellular, Bmpr2 and IDBG-158574 and ENSMUSG00000067336 and 12168, BT.25715 and IDBG-643309 and ENSBTAG00000006420 and 407127