Smo agonist, SAG dihydrochloride
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Catalog number
2801-1
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Price
Please ask
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Size
1 mg
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Alternative_name
N-Methyl-N′-(3-pyridinylbenzyl)-N′-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, dihydrochloride
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Description
SAG hydrochloride is the water-soluble analog of SAG (Cat. No.1939). A cell-permeable Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low concentrations, but can inhibit Smo at very high concentrations.
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CAS Number
364590-63-6
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Structure Available
Y
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Salt Form
No
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Molecular Formula
C₂₈H₂₈ClN₃OS. 2HCl
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Molecular Weight
562.98
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Cell Permeable
Y
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Purity
≥98% by HPLC
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Solubilities
H2O (~ 25 mg/ml) DMSO (~ 10 mg/ml)
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Handling
Protect from light and moisture
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Tag Line
A cell-permeable Smoothened (Smo) agonist
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Storage Condition
-20°C
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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PubChem CID
71433770
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SMILES
CNC1CCC(CC1)N(CC2=CC=CC(=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.O.Cl.Cl
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InChi
InChI=1S/C28H28ClN3OS.2ClH.H2O/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20;;;/h2-8,13-17,22-23,30H,9-12,18H2,1H3;2*1H;1H2
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InChi Key
IYXUQUYRWPGIQL-UHFFFAOYSA-N
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MSDS Available
Yes
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Gene target
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Gene symbol
SAG, RNF7
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Short name
Smo agonist, SAG dihydrochloride
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Alternative name
smoothened, frizzled family receptor agonist, SAG dihydrochloride
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Alternative to gene target
smoothened, frizzled family receptor, FZD11 and Gx and SMOH, SMO and IDBG-40669 and ENSG00000128602 and 6608, Wnt-activated receptor activity, Cell surfaces, Smo and IDBG-132261 and ENSMUSG00000001761 and 319757, SMO and IDBG-635317 and ENSBTAG00000013287 and 539308
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Gene info
Gene info
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Identity
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Gene
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Long gene name
ring finger protein 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1999-05-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Product images
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