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VX 809 for cell activation

VX 809 for cell activation is available 2 times from Biovision labs

2857-5 | VX-809 for cell activation size: 5 mg | 210.27 USD

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2857-25 | VX-809 for cell activation size: 25 mg | 664.73 USD

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Other name 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid; Lumacaftor
Supplied with N/A
Description VX-809 is a novel CFTR corrector that modulates the folding and trafficking of CFTR protein. VX-809 stabilizes an N-terminal domain in CFTR that contains only MSD1 (membrane-spanning domain 1) and efficaciously restores function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains.
Category Biochemicals
Molecular formula C₂₄H₁₈F₂N₂O₅
Is it cell-permeable? Yes
Molecular weight 452.41
Storage condition -20°C
Shipping condition gel pack
Purification ≥98% by HPLC
Peptide sequence N/A
Is this a salt? No
CAS number 936727-05-8
Storage instructions Protect from air and light
Maximum time for storage 36 months
Physical appearance White to off-white solid
Reconstitute instructions DMSO (>90 mg/ml)
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetVX-809 for activation
Short name VX-809 for activation
Technique activation
Alternative name VX-809 to measure cellular activation
Tissue cell
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