PathwayReady™ JAK/STAT Signaling Inhibitor Panel

• Catalog number
  K864-8
• Price
  Please ask
• Size
  8 inhibitors

• Alternative_name
  JAK/STAT Signaling Inhibitor Panel, PathwayReady™
• Description
  A convenient set consisting of eight inhibitors useful for studying JAK/STAT signaling pathway. The inhibitors are: 5 mg of AG 490 (Cat. No. 1570-5), 5 mg of CP-690550 (Cat. No. 1622-5), 500 µg of Lestaurtinib (Cat. No. 1805-500), 5 mg of LLL12 (Cat. No. 1792-5), 50 mg of Pimozide (Cat. No. 1887-50), 5 mg of Stat3 Inhibitor, S3I-201 (Cat. No. 1775-5), 5 mg of Stat3 Inhibitor, Celll-Permeable (Cat. No. 1778-1), and 5 mg of WP1066 (Cat. No. 1809-5).
• CAS Number
  See under the individual product
• Structure Available
  See under the individual product
• Salt Form
  No
• Molecular Formula
  See under the individual product
• Molecular Weight
  See under the individual product
• Cell Permeable
  Yes
• Purity
  ≥95% by HPLC
• Solubilities
  See under the individual product
• Handling
  Protect from air, light and moisture
• Tag Line
  A JAK/STAT pathway signaling inhibitors set
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• SMILES
  N/A
• InChi
  N/A
• InChi Key
  N/A
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. Cell nucleus signaling proteins and molecules are part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be created. STAT proteins are phosphorylated by receptor related kinases and for homo or hetero dimers. JAK-STAT pathways are signaling to the nucleus of the cell.

• Gene target
  PathwayReady™   JAK/STAT   Signaling   Inhibitor   Panel  
• Gene symbol
  JAK3, STAT6, SOAT1
• Short name
  PathwayReady™ JAK/STAT Signaling Inhibitor Panel
• Alternative name
  PathwayReady™ JAK/Signal transducer and activation on transcription Signaling suppressor Panel
• Tissue
  panel

Gene info

• Identity
  HGNC:6193
• Gene
  JAK3
• Long gene name
  Janus kinase 3
• Synonyms
  • L-JAK
  • JAKL
  • LJAK
  • JAK3_HUMAN
  • JAK-3
• Synonyms name
  • tyrosine-protein kinase JAK3
  • leukocyte Janus kinase
• GenBank acession
  • U31601
• Locus
  19p13.11
• Discovery year
  1994-12-19
• Entrez gene record
  3718
• Pubmed identfication
  • 8921370
  • 9226382
• RefSeq identity
  • NM_000215
• Classification
  • Jak family tyrosine kinases
• VEGA ID
  OTTHUMG00000165648
• Locus Specific Databases
  • JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency
  • LRG_77

Gene info

• Identity
  HGNC:11368
• Gene
  STAT6
• Long gene name
  signal transducer and activator of transcription 6
• Synonyms gene name
  • signal transducer and activator of transcription 6, interleukin-4 induced
• Synonyms
  • D12S1644
  • IL-4-STAT
• GenBank acession
  • BC005823
  • BQ028928
• Locus
  12q13.3
• Discovery year
  1995-11-09
• Entrez gene record
  6778
• Pubmed identfication
  • 9605853
  • 8085155
• RefSeq identity
  • NM_003153
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000171194
• Locus Specific Databases
  • LRG_1369

Gene info

• Identity
  HGNC:11177
• Gene
  SOAT1
• Long gene name
  sterol O-acyltransferase 1
• Synonyms gene
  • SOAT
  • STAT
• Synonyms gene name
  • sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
• Synonyms
  • ACAT
  • ACAT1
• Synonyms name
  • acyl-Coenzyme A: cholesterol acyltransferase
• GenBank acession
  • L21934
• Locus
  1q25.2
• Discovery year
  1998-11-04
• Entrez gene record
  6646
• Pubmed identfication
  • 8407899
• RefSeq identity
  • NM_003101
• VEGA ID
  OTTHUMG00000035253

MeSH Data

• Name
  Medical Records
• Concept
  Scope note: Recording of pertinent information concerning patient's illness or illnesses.
• Tree numbers
  • E05.318.308.940.968
• Qualifiers
  classification, economics, legislation & jurisprudence, standards, statistics & numerical data

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