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Bromodomain Inhibitor JQ1

Bromodomain Inhibitor JQ1 is available 2 times from Biovision labs

2070-5 | Bromodomain Inhibitor, (+)-JQ1 size: 5 mg | 502.45 USD

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2070-1 | Bromodomain Inhibitor, (+)-JQ1 size: 1 mg | 172.75 USD

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Alternative_name t-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Description Cell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
CAS Number 1268524-70-4
Structure Available? Yes
Molecular Formula C₂₃H₂₅ClN₄O₂S
Molecular Weight 456.99
Cell-Permeable? Yes
Purity ≥98% by HPLC
Solubilities DMSO (10 mM)
Handling Protect from air and moisture
Tag Line A potent and highly specific BET inhibitor
Storage Condition -20°C
Shipping Condition gel pack
Shelf Life 24 months
MDL Number MFCD19443648
PubChem CID 46907787
SMILES CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
InChi InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15) 25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2, 1-6H3/t17-/m0/s1
InChi Key DNVXATUJJDPFDM-KRWDZBQOSA-N
MSDS Available Yes
Additional description Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Gene targetBromodomain Inhibitor JQ1
Short name Bromodomain Inhibitor, (+)-JQ1
Alternative name Bromodomain suppressor, (and)-JQ1
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