Bromodomain Inhibitor, (+)-JQ1

  • Catalog number
    2070-1
  • Price
    Please ask
  • Size
    1 mg
  • Alternative_name
    t-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
  • Description
    Cell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
  • CAS Number
    1268524-70-4
  • Structure Available
    Yes
  • Molecular Formula
    C₂₃H₂₅ClN₄O₂S
  • Molecular Weight
    456.99
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (10 mM)
  • Handling
    Protect from air and moisture
  • Tag Line
    A potent and highly specific BET inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • MDL Number
    MFCD19443648
  • PubChem CID
    46907787
  • SMILES
    CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
  • InChi
    InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15) 25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2, 1-6H3/t17-/m0/s1
  • InChi Key
    DNVXATUJJDPFDM-KRWDZBQOSA-N
  • MSDS Available
    Yes
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    Bromodomain Inhibitor, (+)-JQ1
  • Alternative name
    Bromodomain suppressor, (+)-JQ1
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