Bromodomain Inhibitor, (+)-JQ1
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Catalog number
2070-1
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Price
Please ask
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Size
1 mg
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Alternative_name
t-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
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Description
Cell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
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CAS Number
1268524-70-4
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Structure Available
Yes
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Molecular Formula
C₂₃H₂₅ClN₄O₂S
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Molecular Weight
456.99
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (10 mM)
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Handling
Protect from air and moisture
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Tag Line
A potent and highly specific BET inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD19443648
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PubChem CID
46907787
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SMILES
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
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InChi
InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15) 25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2, 1-6H3/t17-/m0/s1
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InChi Key
DNVXATUJJDPFDM-KRWDZBQOSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
Bromodomain Inhibitor, (+)-JQ1
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Alternative name
Bromodomain suppressor, (+)-JQ1
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Product images
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