anti-DFF40 Antibody

• Catalog number
  2107
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  DFF40 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN, DFF40, and human CAD, respectively. DFF45/ICAD is the inhibitory protein of DFF40/CAD and forms complex with DFF40/CAD. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death.
• Gene names
  DFF40 Antibody: CAD, CPAN, 40kDa, DFF40, Didff, 5730477D02Rik, Cad, DNA fragmentation factor subunit beta, Caspase-activated deoxyribonuclease, CAD
• Antibodie s label
  unlabelled serum
• Purity
  DFF40 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  DFF40 antibody was made against a peptide corresponding to amino acids near the center of murine CAD. The sequence differs from human DFF40 by two amino acids.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry
• Antibody advice
  DFF40 antibody can be used for detection of DFF40 by Western blot 0.5 ug/mL. A 40 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 5 ug/mL.
• Suspention pH azide
  DFF40 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  DFF40 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  160948620
• Ncbi nr
  NP_031885
• KDa
  40 kDa
• Vial with antibody
  in solution
• NCBI GENE nr
  13368
• GENE symbol
  Dffb
• Antigene name
  DNA fragmentation factor, beta subunit
• Source
  Mus musculus
• Protein nr
  O54788
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DFF40  
• Gene symbol
  DFFB
• Short name
  anti-DFF40 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toDFF40 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2773
• Gene
  DFFB
• Long gene name
  DNA fragmentation factor subunit beta
• Synonyms gene name
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
• Synonyms
  • CAD
  • CPAN
  • DFF-40
  • DFF40
• Synonyms name
  • caspase-activated DNase
• Locus
  1p36.32
• Discovery year
  1997-10-27
• Entrez gene record
  1677
• Pubmed identfication
  • 9108473
  • 9560346
• RefSeq identity
  • NM_001282669
• VEGA ID
  OTTHUMG00000003525

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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