anti-SOCS1 Antibody

• Catalog number
  3765
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  SOCS1 Antibody: The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
• Gene names
  SOCS1 Antibody: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein
• Antibodie s label
  unlabelled serum
• Purity
  SOCS1 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  SOCS1 antibody was made against a 15 amino acid synthetic peptide from near the carboxy terminus of human SOCS1.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  SOCS1 antibody can be used for the detection of SOCS1 by Western blot at 1 - 4 ug/mL.
• Suspention pH azide
  SOCS1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  SOCS1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  8217331
• Ncbi nr
  CAB92528
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  8651
• GENE symbol
  SOCS1
• Antigene name
  suppressor of cytokine signaling 1
• Source
  Homo sapiens
• Protein nr
  O15524
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SOCS1  
• Gene symbol
  SOCS1
• Short name
  anti-SOCS1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toSOCS1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  suppressor of cytokine signaling 1, CIS1 and CISH1 and JAB and SOCS-1 and SSI-1 and SSI1 and TIP3, SOCS1 and IDBG-14621 and ENSG00000185338 and 8651, protein kinase binding, nuclei, Socs1 and IDBG-132667 and ENSMUSG00000038037 and 12703, SOCS1 and IDBG-648701 and ENSBTAG00000004386 and 518795

Gene info

• Identity
  HGNC:19383
• Gene
  SOCS1
• Long gene name
  suppressor of cytokine signaling 1
• Synonyms
  • SOCS-1
  • SSI-1
  • JAB
  • TIP3
  • Cish1
• GenBank acession
  • U88326
• Locus
  16p13.13
• Discovery year
  2002-11-13
• Pubmed identfication
  • 7796808
  • 9266833
• Classification
  • Suppressors of cytokine signaling
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000129792

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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