Mad2L1 Antibody

• Catalog number
  PB9282
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Mad2L1
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB
• Immunogen
  E.coli-derived human Mad2L1 recombinant protein (Position: A2-D205). Human Mad2L1 shares 94% amino acid (aa) sequence identity with mouse Mad2L1.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Mad2L1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Mad2L1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene. This gene belongs to the MAD2 family. It is mapped to 4q27. MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The protein has two highly different native conformations, an inactive open conformation that cannot bind CDC20 and that predominates in cytosolic monomers, and an active closed conformation. It is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment.
• Related articles
  1. Cahill, D. P., da Costa, L. T., Carson-Walter, E. B., Kinzler, K. W., Vogelstein, B., Lengauer, C.Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics 58: 181-187, 1999. 2. "Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)"
• Gene Name
  MAD2L1
• Protein Name
  Mitotic spindle assembly checkpoint protein MAD2A
• Gene Full Name
  MAD2 mitotic arrest deficient-like 1 (yeast)
• Synonyms
  Homolog of MAD2 S cerevisiae antibody|HsMAD 2 antibody|HsMAD2 antibody|Human mitotic feedback control protein Madp2 antibody|MAD 2 antibody|MAD 2A antibody|MAD2 antibody|MAD2 like 1 antibody|MAD2 like protein 1 antibody|MAD2 mitotic arrest deficient like 1 antibody|MAD2-like protein 1 antibody|MAD2A antibody|Mad2l1 antibody|MD2L1_HUMAN antibody|Mitotic arrest deficient 2-like protein 1 antibody|Mitotic arrest deficient like 1 antibody|Mitotic arrest deficient yeast homolog antibody|Mitotic arrest deficient yeast homolog like 1 antibody|Mitotic spindle assembly checkpoint protein antibody|Mitotic spindle assembly checkpoint protein MAD2A antibody
• Uniprot ID
  Q13257
• Entrez GeneID
  4085
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Mad2L1  
• Gene symbol
  MAD2L1-DT, MAD2L1BP, MAD2L1
• Short name
  Mad2L1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Mad2L1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:55546
• Gene
  MAD2L1-DT
• Long gene name
  MAD2L1 divergent transcript
• Locus
  4q27
• Discovery year
  2021-03-24
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:21059
• Gene
  MAD2L1BP
• Long gene name
  MAD2L1 binding protein
• Synonyms
  • CMT2
  • KIAA0110
  • dJ261G23.1
• GenBank acession
  • BC002904
• Locus
  6p21.1
• Discovery year
  2003-06-23
• Entrez gene record
  9587
• Pubmed identfication
  • 7788527
  • 12456649
• RefSeq identity
  • NM_014628
• VEGA ID
  OTTHUMG00000014747

Gene info

• Identity
  HGNC:6763
• Gene
  MAD2L1
• Long gene name
  mitotic arrest deficient 2 like 1
• Synonyms gene name
  • MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
• Synonyms
  • MAD2
  • HSMAD2
• GenBank acession
  • U65410
• Locus
  4q27
• Discovery year
  1996-11-14
• Entrez gene record
  4085
• Pubmed identfication
  • 8824189
  • 9345911
• VEGA ID
  OTTHUMG00000132967

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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