Recombinant Human Endothelial Cell Adhesion Molecule/ESAM Protein(C-Fc) 50µg
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Catalog number
PKSH032380-50µg
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Price
Please ask
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Size
50µg
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Synonym
Endothelial Cell-Selective Adhesion Molecule; ESAM
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Activity
NA
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Sequence
Gln30-Ala247
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Fusion tag
C-Fc
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Accession
Q96AP7
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Expressed Host
Human cells
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Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
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Purity
>95% as determined by reducing SDS-PAGE.
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Endotoxin
<1.0 EU per µg as determined by LAL test.
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Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
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Mol Mass
50.8 kDa
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AP Mol Mass
60 kDa
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Formulation
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
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Reconstitution
Please refer to it for detailed information.
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Background
Endothelial Cell Adhesion Molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein member of the JAM family of immunoglobulin superfamily molecules. The 390 amino acid Human ESAM contains a 216 amino acid extracellular domain (ECD) with a V-type and a C2-type immunoglobulin (Ig) domain. The ECD of human and mouse ESAM share 69% amino acid identity. ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. In addition, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. ESAM-deficient mice were described with lowered angiogenic potential, and accordingly, overexpression of ESAM is closely associated with certain tumor growth and metastasis.
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Description
cell adhesion molecules play a role in cell growth and activation and are often identified by WB or ELISA as in the Recombinant Endothelial Adhesion Molecule/ESAM Protein(C-Fc) 50µg. For cells, cell lines and tissues in culture till half confluency. Whole adhesion and interacting molecules are present in lysates used as reference for ELISA quantification of these molecules and their subunits.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
ESAM, ESAM-AS1
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Short name
Recombinant Endothelial Adhesion Molecule/ESAM Protein(C-Fc) 50µg
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Rec. H. sapiens Endothelial cellular Adhesion Molecule/endothelial cell adhesion molecule Protein(C-fragment c) 50µg
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Alternative technique
rec
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Alternative to gene target
endothelial cell adhesion molecule, ESAM and IDBG-75276 and ENSG00000149564 and 90952, protein binding, Cell surfaces, Esam and IDBG-150411 and ENSMUSG00000001946 and 69524, BT.54007 and IDBG-642621 and ENSBTAG00000001004 and 616926
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Tissue
cell
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Gene info
Gene info
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Identity
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Gene
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Long gene name
ESAM antisense RNA 1
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Locus
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Discovery year
2021-04-07
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Entrez gene record
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RefSeq identity
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Classification
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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