NQO1, human recombinant

  • Catalog number
    7571-50
  • Price
    Please ask
  • Size
    50 ug
  • Synonyms
    NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreductase; Phylloquinone Reductase; Menadione Reductase; Dioxin-inducible 1; Disphorase-4 (DIA4); NAD(P)H Quinone Oxireductase; Quinone Oxidoreductase 1
  • Alternative_names
    NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreductase; Phylloquinone Reductase; Menadione Reductase; Dioxin-inducible 1; Disphorase-4 (DIA4); NAD(P)H Quinone Oxireductase; Quinone Oxidoreductase 1
  • Description
    Catalyzes the reduction of highly reactive quinone metabolites and their derivatives
  • Recombinant
    Yes
  • Source
    E. coli
  • Purity by SDS PAGE
    ≥90%
  • Assay
    SDS-PAGE
  • Molecular Weight
    ~30.0 kDa. Human NQO1 (aa 1-274) is fused at the C-terminus to a His-tag.
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    6 months
  • Appearance
    Liquid
  • Physical form description
    0.2 um-filtered solution in 50 mM Tris-Cl, pH 8.0, containing 1 mM DTT.
  • Background Information
    NQO1 is a cytosolic antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites and their derivatives by using NAD (P)H as an electron donor. Thus NQO1 acts as a detoxifying enzyme and is involved in the body’s protection against oxidative stress. NQO1 acts as a protein chaperone, one of its targets being p53. In humans NQO1 is expressed at high levels in adipocytes and its expression levels are positively correlated with adiposity, glucose tolerance, and makers of liver dysfunction. Altered expression of NQO1 is associated with Alzheimer’s disease. NQO1 is abnormally elevated in many types of solid tumors and may represent a useful biomarker of pancreatic cancer.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    NQO1  
  • Gene symbol
    NQO1-DT, NQO1
  • Short name
    NQO1, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Human, Humans
  • Alternative name
    Nicotinamide adenine dinucleotide(P)H dehydrogenase, quinone 1, H. sapiens Rec.
  • Alternative technique
    rec
  • Alternative to gene target
    NAD(P)H dehydrogenase, quinone 1, DHQU and DIA4 and DTD and NMOR1 and NMORI and QR1, NQO1 and IDBG-39427 and ENSG00000181019 and 1728, cytochrome-b5 reductase activity, Cytoplasm, Nqo1 and IDBG-190808 and ENSMUSG00000003849 and 18104, NQO1 and IDBG-634590 and ENSBTAG00000020632 and 519632
Gene info
  • Identity
  • Gene
  • Long gene name
    NQO1 divergent transcript
  • Locus
  • Discovery year
    2020-11-04
  • Classification
    • Divergent transcripts
Gene info
  • Identity
  • Gene
  • Long gene name
    NAD(P)H quinone dehydrogenase 1
  • Synonyms gene
  • Synonyms gene name
    • diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
    • NAD(P)H dehydrogenase, quinone 1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-06-22
  • Entrez gene record
  • Pubmed identfication
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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