SMAD1 Antibody

• Catalog number
  F47786-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  SMAD1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the SMAD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This SMAD1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q15797
• Purity
  Antigen affinity
• Description
  The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
• Immunogen
  A portion of amino acids 1-30 from the human protein was used as the immunogen for this SMAD1 antibody.
• Storage
  Aliquot the SMAD1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SMAD1  
• Gene symbol
  SMAD1-AS2, SMAD1-AS1, SMAD1, GARS1
• Short name
  Anti-SMAD1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to SMAD1
• Alternative technique
  antibodies
• Alternative to gene target
  SMAD family member 1, BSP-1 and BSP1 and JV4-1 and JV41 and MADH1 and MADR1, SMAD1 and IDBG-39936 and ENSG00000170365 and 4086, transforming growth factor beta receptor, nuclei, Smad1 and IDBG-170516 and ENSMUSG00000031681 and 17125, SMAD1 and IDBG-629431 and ENSBTAG00000002835 and 540488

Gene info

• Identity
  HGNC:49381
• Gene
  SMAD1-AS2
• Long gene name
  SMAD1 antisense RNA 2
• GenBank acession
  • BC042377
• Locus
  4q31.21
• Discovery year
  2013-10-22
• Entrez gene record
  101927659
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000162185

Gene info

• Identity
  HGNC:49379
• Gene
  SMAD1-AS1
• Long gene name
  SMAD1 antisense RNA 1
• Synonyms
  • ENST00000513542
• GenBank acession
  • AW087665
• Locus
  4q31.21
• Discovery year
  2013-10-22
• Pubmed identfication
  • 24147006
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000162186

Gene info

• Identity
  HGNC:6767
• Gene
  SMAD1
• Long gene name
  SMAD family member 1
• Synonyms gene
  • MADH1
• Synonyms gene name
  • MAD, mothers against decapentaplegic homolog 1 (Drosophila)
  • SMAD, mothers against DPP homolog 1 (Drosophila)
• Synonyms
  • MADR1
  • JV4-1
• GenBank acession
  • U59423
• Locus
  4q31.21
• Discovery year
  1996-11-15
• Entrez gene record
  4086
• Pubmed identfication
  • 8653785
  • 8673135
• RefSeq identity
  • NM_005900
• Classification
  • SMAD family
• VEGA ID
  OTTHUMG00000161592

Gene info

• Identity
  HGNC:4162
• Gene
  GARS1
• Long gene name
  glycyl-tRNA synthetase 1
• Synonyms gene
  • CMT2D
  • GARS
• Synonyms gene name
  • Charcot-Marie-Tooth neuropathy 2D
  • glycyl-tRNA synthetase
• Synonyms
  • GlyRS
  • DSMAV
  • SMAD1
• Synonyms name
  • glycine tRNA ligase
• GenBank acession
  • AK074524
• Locus
  7p14.3
• Discovery year
  1995-03-21
• Entrez gene record
  2617
• Pubmed identfication
  • 8595897
  • 8872480
• RefSeq identity
  • NM_002047
• Classification
  • Aminoacyl tRNA synthetases, Class II
• VEGA ID
  OTTHUMG00000152769
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_243

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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