Category
Conjugated Primary Antibodies
Host Organism
Rabbit (Oryctolagus cuniculus)
Target Antigen
HIV1 gp120
Specificity
This is a highly specific antibody against HIV1 gp120.
Modification
Unmodified
Modification site
None
Clonality
Polyclonal
Clone
Polyclonal antibody
Concentration
1ug per 1ul
Immunogen_range
290-340/857
Subcellular location
Extracellular
Source
KLH conjugated synthetic peptide derived from HIV1 Surface protein gp120
Swiss Prot
P05877
Crossreactivity
Virus
Crossreactive species details
HIV-1 M:B_MN
Antigen background
The attachment of enveloped viruses to cells and the fusion of viral and cellular membranes are critical early events in the HIV viral infection. This process is mediated by envelope glycoproteins (gp) on the surface of the virus. The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein, gp160, is proteolytically cleaved into gp120 and gp41, which remain noncovalently associated with one another. gp120 is one of the proteins that forms the envelope of HIV. gp120 projects from the surface of HIV and binds to the CD4 molecule on helper T cells. gp120 has been a logical experimental HIV vaccine because the outer envelope is the first part of the virus that encounters antibody. gp41 is embedded in the outer envelope of HIV that anchors gp120. gp41 also plays a key role in HIV's infection of CD4+ T cells by facilitating the fusion of the viral and cell membranes. The nomenclature of the gp proteins describes their respective molecular masses (e.g., gp160, gp120, gp41).
Purification method
This antibody was purified via Protein A.
Synonyms
HIV-1 ENV gp120; HIV1 gp120; HIV1gp120; HIV-1 gp120; Envelope surface glycoprotein gp120; Glycoprotein 120; gp120; gp120 glycoprotein; Human Immunodeficiency Virus 1; SU; Surface protein; ENV_HV1MN; Envelope glycoprotein gp160; Env polyprotein; Surface protein gp120; SU.
Gene targetHIV1
gp120
Conjugated
Short name
Anti-HIV1 gp120
Isotype
Immunoglobulin G (IgG)
Alternative technique
antibodies
Virus
hiv1
