Glutaminase C-IN-1 (968)
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Catalog numberB1198-5
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PricePlease ask
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Size5 mg
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Alternative_name5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one
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DescriptionGlutaminase C-IN-1 (968) a cell-permeable, reversible inhibitor of a mitochrondrial glutaminase splice variant, glutaminase C (IC₅₀ = ~2.5 µM), which is commonly found in cancer cells. Glutaminase C-IN-1 (968) blocks transformation induced by Rho GTPases and inhibits the proliferation of non-invasive epithelial (T-47D and MDA-MB-361) and invasive mesenchymal (MDA-MB-231 and Hs578T) cancer cells, without affecting normal cells. Glutaminase C-IN-1 (968) induces apoptosis and alters both histone methylation and gene expression in cancer cells.
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CAS Number311795-38-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₇H₂₇BrN₂O
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Molecular Weight475.42
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>5 mg/ml)
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HandlingProtect from air and light
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Tag LineA reversible inhibitor of a mitochrondrial glutaminase
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID3099980
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SMILESCC1(CC2=C(C(NC3=C2C4=CC=CC=C4C=C3)C5=CC(=C(C=C5)N(C)C)Br)C(=O)C1)C
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InChiInChI=1S/C27H27BrN2O/c1-27(2)14-19-24-18-8-6-5-7-16(18)9-11-21(24)29-26(25(19)23(31)15-27)17-10-12-22(30(3)4)20(28)13-17/h5-13,26,29H,14-15H2,1-4H3
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InChi KeyNVFRRJQWRZFDLM-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolPFDN4, FOS, JUN, TAC4, ROS1, RAF1, SMC4, ERVFC1-1, SLCO1B1
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Short nameGlutaminase C-IN-1 (968)
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Alternative nameGlutaminase C-IN-1 (968)
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Gene info
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Identity
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Gene
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Long gene nameprefoldin subunit 4
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Synonyms gene name
- prefoldin 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-08-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Prefoldin subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameFos proto-oncogene, AP-1 transcription factor subunit
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Synonyms gene name
- v-fos FBJ murine osteosarcoma viral oncogene homolog
- FBJ murine osteosarcoma viral oncogene homolog
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fos transcription factor family
- Basic leucine zipper proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameJun proto-oncogene, AP-1 transcription factor subunit
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Synonyms gene name
- v-jun avian sarcoma virus 17 oncogene homolog
- jun oncogene
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Synonyms
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GenBank acession
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Locus
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Discovery year1988-05-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Basic leucine zipper proteins
- Jun transcription factor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametachykinin precursor 4
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Synonyms gene name
- tachykinin 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-10-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tachykinin precursors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameROS proto-oncogene 1, receptor tyrosine kinase
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Synonyms gene name
- v-ros avian UR2 sarcoma virus oncogene homolog 1
- v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
- c-ros oncogene 1 , receptor tyrosine kinase
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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Classification
- Receptor tyrosine kinases
- Fibronectin type III domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameRaf-1 proto-oncogene, serine/threonine kinase
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Synonyms gene name
- v-raf-1 murine leukemia viral oncogene homolog 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mitogen-activated protein kinase kinase kinases
- RAF family
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namestructural maintenance of chromosomes 4
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Synonyms gene
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Synonyms gene name
- SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
- SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-02-22
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Entrez gene record
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Pubmed identfication
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Classification
- Structural maintenance of chromosomes proteins
- Condensin I subunits
- Condensin II subunits
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameendogenous retrovirus group FC1 member 1, envelope
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Synonyms gene name
- endogenous retrovirus group FC1, member 1
- endogenous retrovirus group FC1 member 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2011-05-05
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Entrez gene record
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Pubmed identfication
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Classification
- Envelope ERV derived genes
Gene info
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Identity
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Gene
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Long gene namesolute carrier organic anion transporter family member 1B1
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Synonyms gene
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Synonyms gene name
- solute carrier family 21 (organic anion transporter), member 6
- solute carrier organic anion transporter family, member 1B1
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Synonyms
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Locus
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Discovery year1999-11-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Solute carriers
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VEGA ID
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Locus Specific Databases
