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Products_type
Antibody
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Products_short_name
[ESA / EPCAM]
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Products_name_syn
[Anti-ESA / EPCAM Antibody (clone VU-1D9) IHC-plus; EPCAM; 323/A3; ACSTD1; 17-1A; CD326; EGP; EGP34; Epithelial glycoprotein; GA733-2; HNPCC8; Ep-CAM; ESA; HEGP314; KS 1/4 antigen; KS1/4; KSA; M1S2; MIC18; MK-1; MH99; TROP1; TACST-1; TACSTD1; CD326 antigen; CO-17A; DIAR5; EGP-2; EGP314; EGP40; Human ESA; EPCAM]
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Other_names
[epithelial cell adhesion molecule; Epithelial cell adhesion molecule; epithelial cell adhesion molecule; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); epithelial cell adhesion molecule; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD_antigen: CD326]
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Products_gene_name
[ESA]
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Products_gene_name_syn
[EPCAM]
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Other_gene_names
[EPCAM; EPCAM; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Ep-CAM; EGP; EGP314; hEGP314]
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Clonality
Monoclonal
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Clone
[VU-1D9]
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Reactivity
Human
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Specificity
Ep-Cam (also called ESA, EGP40, 17-1A antigen, KSA, GA7333-2) is a 40kD epithelial protein expressed on baso-lateral cell surfaces in very many epithelial tissues (but absent from mesothelial tissues). The extracellular domain has a cysteine-rich repeat and a small domain with homology to nidogen. It is a homophyllic cell-cell adhesion molecule, recently called Ep-CAM (Litvinov et al., 1994). It reacts with most epithelial cells and carcinomas.
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Purity
Purified
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Form
PBS, 15 mM sodium azide, pH 7.4
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Storage_stability
Store at 4 degree C.
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Tested_application
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Gene target
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Gene symbol
EPCAM-DT, PON1, FLOT2, EPCAM
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Short name
Mouse Monoclonal [clone VU-1D9] (IgG1) ESA / EPCAM
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Technique
Mouse monoclonal, Mouse, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Isotype
IgG1, IgG1
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Species
Human, Humans, Mouses
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Alternative name
Mouse monoclonal [clonality VU-1D9] (IgG1) to H. sapiens ESA / epithelial cellular adhesion molecule
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Alternative technique
murine
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Alternative to gene target
epithelial cell adhesion molecule, DIAR5 and EGP-2 and EGP314 and EGP40 and ESA and HNPCC8 and KS1/4 and KSA and M4S1 and MIC18 and MK-1 and TACSTD1 and TROP1, EPCAM and IDBG-50831 and ENSG00000119888 and 4072, protein complex binding, Cell surfaces, Epcam and IDBG-201437 and ENSMUSG00000045394 and 17075, EPCAM and IDBG-633617 and ENSBTAG00000006474 and 514039
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Clone name
VU-1D9
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