DUB Inhibitor, PR-619
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Catalog number2302-5
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PricePlease ask
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Size5 mg
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Alternative_name2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine
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DescriptionA cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs). Treatment of cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.
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CAS Number2645-32-1
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Structure AvailableYes
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Peptide sequenceNo
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Salt FormNo
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Molecular FormulaC₇H₅N₅S₂
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Molecular Weight223.28
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~ 5 mg/ml)
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HandlingProtect from air and light
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Tag LineA deubiquitinylating enzymes (DUB) inhibitor
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Storage Condition-20 ̊C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD00830384
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SMILESN#CSC1=C(N)N=C(N)C(SC#N)=C1
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InChiInChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
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InChi KeyZXOBLNBVNROVLC-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolPRH2, TMEM37, PGR, MIR619, KMT5A, PRTN3
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Short nameDUB Inhibitor, PR-619
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Alternative nameDUB suppressor, PR-619
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Gene info
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Identity
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Gene
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Long gene nameproline rich protein HaeIII subfamily 2
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Synonyms
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Synonyms name
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Proline rich proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametransmembrane protein 37
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Synonyms
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GenBank acession
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Locus
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Discovery year2004-12-14
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprogesterone receptor
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- Nuclear receptor subfamily 3 group C
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 619
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Synonyms gene
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Synonyms
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Locus
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Discovery year2006-05-17
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNAs
Gene info
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Identity
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Gene
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Long gene namelysine methyltransferase 5A
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Synonyms gene
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Synonyms gene name
- SET domain containing (lysine methyltransferase) 8
- lysine (K)-specific methyltransferase 5A
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- SET domain containing
- Lysine methyltransferases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameproteinase 3
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Synonyms
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Synonyms name
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Locus
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Discovery year1992-08-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Granule associated serine proteases of immune defence
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VEGA ID