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Human Recombinant TXNRD1

Human Recombinant TXNRD1 is available 1 time from Biovision labs

6330-100 | Human Recombinant TXNRD1 size: 100 ug | 495.28 USD

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Synonyms Human Recombinant TXNRD1
Alternative_names Thioredoxin Reductase, GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR.
Description A protein involved in redox signaling
Recombinant Yes
Source E. Coli
Purity by SDS-PAGE ≥95%
Assay SDS-PAGE
Biological activity Specific activity is 0.48-0.60 units/ml
Unit Definition Specific activity is 0.48-0.60 units/ml, and was measured in a coupled assay with DTNB and NADPH. The amount of TNB generated by NADPH was measured in absorbance at 412 nm.
Molecular Weight 55.7 kDa
Storage Temp. -20°C
Shipping gel pack
Shelf Life 12 months
Concentration 0.5 mg/ml
Appearance Liquid
Physical form description 0.5 mg/ml solution in PBS (pH 7.4) containing 10% glycerol.
Background Information Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene. This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases
Amino acid sequence MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM VRSILLRGFD QDMANKIGEH MEEHGIKFIR QFVPIKVEQI EAGTPGRLRV VAQSTNSEEI IEGEYNTVML AIGRDACTRK IGLETVGVKI NEKTGKIPVT DEEQTNVPYI YAIGDILEDK VELTPVAIQA GRLLAQRLYA GSTVKCDYEN VPTTVFTPLE YGACGLSEEK AVEKFGEENI EVYHSYFWPL EWTIPSRDNN KCYAKIICNT KDNERVVGFH VLGPNAGEVT QGFAAALKCG LTKKQLDSTI GIHPVCAEVF TTLSVTKRSG ASILQAGC
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetTXNRD1
Short name Recombinant TXNRD1
Technique Recombinant
Species Human
Alternative name H. sapiens recombinant TXNRD1
Alternative technique rec
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