YM-01, Hsp70 Inhibitor

  • Catalog number
    SIH-121-25MG
  • Price
    Please ask
  • Size
    25 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    409086-68-6
  • Description
    Hsp70 Inhibitor
  • Molecular weight
    417.97 g/mol
  • Primary research fields
    Cancer, Heat Shock
  • Other name
    2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride; YM-1
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C20H20ClN3OS2
  • Origin
    Synthetic
  • Purity pourcentage
    >98% (HPLC)
  • Soluble in
    Soluble in warm water (2 mg/ml)
  • Physical appearance
    Orange red solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
  • PubChem number
    Refer to PubChem
  • Scientific context
    YM-01 is an allosteric Hsp70 inhibitor. It binds with in Hsp70's nucleotide binding domain, adjacent to ATP/ADP binding pocket. It inhibits J-stimulated ATP turnover rate. It blocks Hsc70-bag1 interaction both in vitro and in vivo and enhances binding of Hsp70 to misfolded proteins. It reduces tau levels in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells, and endogenous tau in primary neuron from rTg4510 mice, with EC50's of low micromolar. It recovers long-term potentiation deficits in brain slices from rTg4510 mice. It also has anti-cancer activity, with an EC50 value of low micromolar against several cancer cell lines. It destabilizes oncoproteins in cells, including Akt and Raf-1. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at more.
  • Bibliography
    1. Wang et al., 2013 Nature Chem. Biol. 9: 112-118. 2. Abisambra et al., 2013 Biol. Psychiatry, 74: 367-374. 3. Koren et al. PLoS One 7:e35566. 4. Morishima et al. 2011 Biochemistry. 50: 7146. 5. Davis et al. 2012 J. Immunol. 189: 4488.
  • Release date
    4-Dec-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of YM-01 (SIH-121), a Hsp70 Inhibitor. CAS #: 409086-68-6. Molecular Formula: C20H20ClN3OS2. Molecular Weight: 417.97 g/mol. Chemical structure of YM-01, a Hsp70 Inhibitor (SIH-121). CAS # 409086-68-6. Molecular Formula: C20H20ClN3OS2.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.025
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
    YM-01   Hsp70   Inhibitor  
  • Gene symbol
    HCG4P1, METTL13
  • Short name
    YM-01, Hsp70 Inhibitor
  • Alternative name
    YM-01, Hsp70 suppressor
Gene info
Gene info
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