Neutrophil Elastase (ELANE) (Native Protein)
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Catalog number
30 600 202
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Price
Please ask
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Size
25 µg
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Protein type
Native
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Protein subtype
EC 3.4.21.37
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Protein family
Member of a serine proteases that hydrolyze many proteins in addition to elastin
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Protein description
ELANE modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
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Research area interests
Diseases associated with ELANE include Neutropenia, Cyclic and Neutropenia, Severe Congenital 1, Autosomal Dominant. Among its related pathways are amb2 Integrin signaling and Cell adhesion_Cell-matrix glycoconjugates.
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Package form
liquid
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Tested applications
Degradation of extracellular matrix components such as elastin, cartilage proteoglycans, collagens, fibronectin; Screening and characterization of inhibitors; Drug target for emphysema, cystic fibrosis, adult respuratory stress syndrome and other diseases
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Other names
Bone Marrow Serine Protease, Human Leukocyte Elastase, ELANE (Elastase, Neutrophil Expressed)
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Peptide sequence
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGMTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
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Available target modification
No
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Expression system
Human Blood
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Product Subtype
full length
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Active form
Yes
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Tag
untagged
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Contents
10 mM acetate buffer pH 5.5
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Protein purity
>95%
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Molecular weight
29 kDa
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UniProt number
P08246
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Gene number
1991
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Abbreviation
ELANE
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Full name
elastase, neutrophil expressed
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Other desciption
Human neutrophil elastase (EC 3.4.21.37) from human neutrophils. Prepared from whole human blood shown to be non-reactive for HbsAG, antiHCV, anti-HBc, and negative for anti-HIV1 2 by FDA approved tests. The protein consists of a single polypeptide chain of 218 amino acids I30 ... Q247 with a relative molecular weight of about 29.5 kDa.
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Purification
Mentioned in the data sheet
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PubMed citations
See the data sheet
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Warnings
For Research Use only.
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Shipping conditions
dry ice
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Storage condition
Store at -70°C
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Technical datasheet
Contact us to receive the datasheet
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Gene target
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Gene symbol
ELANE
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Short name
Neutrophil Elastase (ELANE) (Native Protein)
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Species
Homo sapiens
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Alternative name
Neutrophil Elastase (elastase, neutrophil expressed) (Native Protein)
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Alternative to gene target
elastase, neutrophil expressed, ELA2 and GE and HLE and HNE and NE and PMN-E and SCN1, ELANE and IDBG-13111 and ENSG00000197561 and 1991, cytokine binding, Extracellular, Elane and IDBG-171367 and ENSMUSG00000020125 and 50701, ELA2 and IDBG-645525 and ENSBTAG00000046188 and 100126050
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Gene info
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