Caspase-3 Substrate DEVD-pNA

  • Catalog number
    1008-200
  • Price
    Please ask
  • Size
    200 assays
  • Alternative_name
    Ac-DEVD-pNA, Caspase-3 Substrate, Colorimetric
  • Description
    Ready-to-use colorimetric substrate for CPP32/caspase-3 and related caspases that recognize the amino acid sequence DEVD. The sequence DEVD is based on caspase-3 cleavage site in poly (ADP-ribose) polymerase (PARP). CPP32 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l = 400 nm) after cleavage from the peptide substrate DEVD-pNA, using a spectrophotometer or multi-well plate reader. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amounts of caspase assays.
  • Structure Available
    No
  • Peptide sequence
    Ac-Asp-Glu-Val-Asp-pNA
  • Salt Form
    No
  • Molecular Formula
    C₂₆H₃₄N₆O₁₃
  • Molecular Weight
    638.58
  • Cell Permeable
    No
  • Purity
    >98% by HPLC
  • Handling
    Protect from light and moisture
  • Tag Line
    Caspase-3 substrate
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    6-12 months
  • MDL Number
    MFCD00792707
  • PubChem CID
    4329
  • SMILES
    CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C
  • InChi
    InChI=1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)
  • InChi Key
    GGXRLUDNGFFUKI-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Additional description
    Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
MeSH Data
  • Name
  • Concept
    Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
  • Tree numbers
    • E05.599.495
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