Caspase-3 Substrate DEVD-pNA
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Catalog number1008-200
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PricePlease ask
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Size200 assays
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Alternative_nameAc-DEVD-pNA, Caspase-3 Substrate, Colorimetric
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DescriptionReady-to-use colorimetric substrate for CPP32/caspase-3 and related caspases that recognize the amino acid sequence DEVD. The sequence DEVD is based on caspase-3 cleavage site in poly (ADP-ribose) polymerase (PARP). CPP32 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l = 400 nm) after cleavage from the peptide substrate DEVD-pNA, using a spectrophotometer or multi-well plate reader. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amounts of caspase assays.
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Structure AvailableNo
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Peptide sequenceAc-Asp-Glu-Val-Asp-pNA
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Salt FormNo
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Molecular FormulaC₂₆H₃₄N₆O₁₃
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Molecular Weight638.58
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Cell PermeableNo
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Purity>98% by HPLC
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HandlingProtect from light and moisture
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Tag LineCaspase-3 substrate
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life6-12 months
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MDL NumberMFCD00792707
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PubChem CID4329
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SMILESCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C
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InChiInChI=1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)
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InChi KeyGGXRLUDNGFFUKI-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionHuman and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
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Gene target
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Short nameCaspase-3 Substrate DEVD-pNA
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Alternative namecaspase-3 Substrate DEVD-pNA
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MeSH Data
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Name
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ConceptScope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
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Tree numbers
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