MLL5 Antibody, ALEXA FLUOR 647

• Catalog number
  bs-5273R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  MLL5 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-MLL5 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  MLL5
• Specificity
  This is a highly specific antibody against MLL5.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  310-360/1858
• Subcellular location
  Cytoplasm, Nucleus, Cell membrane
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MLL5
• Gene ID Number
  55904
• Swiss Prot
  Q8IZD2
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. Isoform NKp44L: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  MLL5; NKp44L; HDCMC04P; Histone-lysine N-methyltransferase 2E; Lysine N-methyltransferase 2E; Myeloid/lymphoid or mixed-lineage leukemia protein 5; KMT2E
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-MLL5 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  MLL5  
• Gene symbol
  KMT2E
• Short name
  Anti-MLL5
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  MLL5 Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies
• Alternative to gene target
  myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila), MLL5 and IDBG-34737 and ENSG00000005483 and 55904, histone methyltransferase activity (H3-K4 specific), nuclei, Mll5 and IDBG-139425 and ENSMUSG00000029004 and 69188, MLL5 and IDBG-631821 and ENSBTAG00000009207 and 539121

Gene info

• Identity
  HGNC:18541
• Gene
  KMT2E
• Long gene name
  lysine methyltransferase 2E (inactive)
• Synonyms gene
  • MLL5
• Synonyms gene name
  • myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
  • lysine (K)-specific methyltransferase 2E
  • lysine methyltransferase 2E
• Synonyms
  • HDCMC04P
• GenBank acession
  • AF067804
• Locus
  7q22.3
• Discovery year
  2002-06-07
• Entrez gene record
  55904
• Pubmed identfication
  • 9218106
  • 7672722
  • 27812132
  • 31079897
• Classification
  • PHD finger proteins
  • SET domain containing
  • Lysine methyltransferases
• VEGA ID
  OTTHUMG00000157403
• Locus Specific Databases
  • LRG_1404

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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