Chelerythrine chloride

• Catalog number
  2064-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
• Description
  Cell-permeable. A selective protein kinase C (PKC) inhibitor (IC₅₀ =0.66 µM). Chelerythrine is at least 100-fold more selective for PKCs than for other kinases. It induces apoptotic cell death in polymorphonuclear leukocyte through activation of caspase-3. In addition, Chelerythrine treated cells underwent apoptosis, with features that suggest involvement of the mitochondrial pathway, and through a mechanism that involves inhibition of the anti-apoptotic inhibitor BclXL.
• CAS Number
  3895-92-9
• Structure Available
  Yes
• Molecular Formula
  C₂₁H₁₈NO₄Cl
• Molecular Weight
  383.82
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (> 10 mg/ml) or H₂O (5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A selective protein kinase C (PKC) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00060717
• PubChem CID
  72311
• PubChem CID Link
• SMILES
  C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
• InChi
  InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1
• InChi Key
  WEEFNMFMNMASJY-UHFFFAOYSA-M
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Chelerythrine   chloride  
• Short name
  Chelerythrine chloride
• Alternative name
  Chelerythrine chloride

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