SMI-4a

• Catalog number
  2211-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
• Description
  A selective, ATP-competitive inhibitor Pim-1 (IC₅₀ = 21 nM) and Pim-2 (IC₅₀ = 100 nM) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.
• CAS Number
  327033-36-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₁H₆F₃NO₂S
• Molecular Weight
  273.23
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A pim kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24months
• MDL Number
  MFCD01152003
• PubChem CID
  1361334
• PubChem CID Link
• SMILES
  C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2
• InChi
  InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-
• InChi Key
  NGJLOFCOEOHFKQ-YVMONPNESA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SMI-4a  
• Short name
  SMI-4a
• Alternative name
  SMI-4a

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