MSH2 Antibody

• Catalog number
  3429-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  MSH2
• Target Alternative Name
  HNPCC , COCA1 , Flow cytometryC1 , HNPCC1 , BAT-26 , Familial Nonpolyposis Colon Cancer Type 1 , Colorectal Cancer Type 1
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Synthetic peptide mapping to a region between 1-50 of MSH2
• Accession
  P43246
• Gene Id
  4436
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.2 mg/ml
• Formulation
  100 µg (0.2 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide.
• Purification
  Affinity purified
• Application
  Western blot, Immunoprecipitation, Immunohistochemistry
• Application And Usages
  Western blotting (1-4 µg/ml), immunoprecipitation (15-25 µg/ml), and Immunohistochemistry (15-25 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes the MSH2 of human, mouse, and rat origins. Reactivity to other species has not been tested.
• Description
  DNA mismatch repair genes have been found to be associated with hereditary nonpolyposis colorectal cancer (HNPCC). Inherited mutations in the MSH2 were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability sμggests that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MSH2  
• Gene symbol
  MSH2-OT1, MSH2
• Short name
  MSH2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli), COCA1 and FCC1 and HNPCC and HNPCC1 and LCFS2, MSH2 and IDBG-50900 and ENSG00000095002 and 4436, ADP binding, nuclei, Msh2 and IDBG-201483 and ENSMUSG00000024151 and 17685, MSH2 and IDBG-633627 and ENSBTAG00000002742 and 533115

Gene info

• Identity
  HGNC:40319
• Gene
  MSH2-OT1
• Long gene name
  MSH2 overlapping transcript 1
• Locus
  2p16.3
• Discovery year
  2019-08-15
• Entrez gene record
  644093
• RefSeq identity
  • NR_120602
• Classification
  • Overlapping transcripts

Gene info

• Identity
  HGNC:7325
• Gene
  MSH2
• Long gene name
  mutS homolog 2
• Synonyms gene
  • COCA1
• Synonyms gene name
  • mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1)
  • mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
• Synonyms
  • HNPCC
  • HNPCC1
• Synonyms name
  • DNA mismatch repair protein Msh2
• GenBank acession
  • U03911
• Locus
  2p21-p16.3
• Discovery year
  1993-07-28
• Entrez gene record
  4436
• Pubmed identfication
  • 8484120
  • 9843200
• Classification
  • MutS homologs
• VEGA ID
  OTTHUMG00000128861
• Locus Specific Databases
  • Hereditary Non-Polyposis Colorectal Cancer, HNPCC
  • Global Variome shared LOVD
  • MSH2 database at LOVD-China
  • LOVD - Leiden Open Variation Database
  • LRG_218

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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