anti-SMURF1 Antibody

• Catalog number
  7945
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1). SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2). SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3). SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4).
• Gene names
  SMAD specific E3 ubiquitin protein ligase 1, SMAD ubiquitination regulatory factor 1, E3 ubiquitin-protein ligase SMURF1
• Antibodie s label
  unlabelled serum
• Purity
  SMURF1 antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  SMURF1 antibody is human, mouse and rat reactive. At least three isoforms of SMURF1 are known to exist this antibody will recognize all three isoforms. SMURF1 is predicted to not cross-react with SMURF2.
• Antigen
  SMURF1 antibody was made against a 16 amino acid peptide near the amino terminus of human SMURF1.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry
• Antibody advice
  SMURF1 body can be used for detection of SMURF1 by Western blot at 1 - 2 ug/ml. Antibody can also be used for Immunohistochemistry starting at 5 ug/mL.
• Suspention pH azide
  SMURF1 antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  SMURF1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
• Works with
  Human, Mouse, Rat
• Omim nr
  31317292
• Ncbi nr
  NP_065162
• KDa
  Predicted: 80, 83 kDa Observed: 78 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  57154
• GENE symbol
  SMURF1
• Antigene name
  SMAD specific E3 ubiquitin protein ligase 1
• Source
  homo sapiens
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SMURF1  
• Gene symbol
  SMURF1
• Short name
  anti-SMURF1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toSMAD specific E3 ubiquitin protein ligase 1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  SMAD specific E3 ubiquitin protein ligase 1, SMURF1 and IDBG-28871 and ENSG00000198742 and 57154, R-SMAD binding, nuclei, Smurf1 and IDBG-208404 and ENSMUSG00000038780 and 75788, SMURF1 and IDBG-640859 and ENSBTAG00000007118 and

Gene info

• Identity
  HGNC:16807
• Gene
  SMURF1
• Long gene name
  SMAD specific E3 ubiquitin protein ligase 1
• Synonyms
  • KIAA1625
• GenBank acession
  • AB046845
• Locus
  7q22.1
• Discovery year
  2004-07-29
• Entrez gene record
  57154
• Pubmed identfication
  • 10458166
• RefSeq identity
  • NM_020429
• Classification
  • HECT domain containing
• VEGA ID
  OTTHUMG00000150272

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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