CD39 monoclonal antibody

• Catalog number
  11-184-C025
• Price
  Please ask
• Size
  25ug

• Long name
  Mouse Monoclonal Antibody against Human CD39, Clone: TU66
• Antigen
  CD39
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  TU66
• Applications
  FC
• Format conjugation
  purified; unconjugated
• Specificity
  The mouse monoclonal antibody TU66, also known as Tü66, recognizes CD39, a 78 kDa cell surface enzyme expressed by regulatory T cells, mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets._x000D_ HLDA IV; WS Code A54
• Research area
  CD and Related Antigens (Human)
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD39, Clone: TU66 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), is a cell surface enzyme (with intracellular N- and C-terminus) which hydrolyzes extracellular ATP and ADP to AMP. Inhibition of its enzymatic activity may confer anticancer benefits. The formation of oligomers in the plasma membrane is essential for enzyme activity. It is expressed on Treg cells, and in other cell types, such as mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets. Hydrolysis of ATP and ADP inhibits inflammatory and thrombotic responses. In the nervous system, it regulates purinergic neurotransmission.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  *Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, Höpner S, Centonze D, Bernardi G, Dell'Acqua ML, Rossini PM, Battistini L, Rötzschke O, Falk K: Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 2007 Aug 15;110(4):1225-32., *Nikolova M, Carriere M, Jenabian MA, Limou S, Younas M, Kök A, Huë S, Seddiki N, Hulin A, Delaneau O, Schuitemaker H, Herbeck JT, Mullins JI, Muhtarova M, Bensussan A, Zagury JF, Lelievre JD, Lévy Y: CD39/adenosine pathway is involved in AIDS progression. PLoS Pathog. 2011 Jul;7(7):e1002110., *Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, Polhill T, Wang Y, Zheng G, Wang Y, Lee VW, Unwin RJ, Harris DC, Dwyer KM, Alexander SI: Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol. 2012 Sep;42(9):2441-51., Younas M, Hue S, Lacabaratz C, Guguin A, Wiedemann A, Surenaud M, Beq S, Croughs T, Lelièvre JD, Lévy Y: IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis. J Immunol. 2013 Sep 15;191(6):3161-8., Coppola A, Coppola L, dalla Mora L, Limongelli FM, Grassia A, Mastrolorenzo L, Gombos G, Lucivero G: Vigorous exercise acutely changes platelet and B-lymphocyte CD39 expression. J Appl Physiol (1985). 2005 Apr;98(4):1414-9., *Gadeock S, Tran JN, Georgiou JG, Jalilian I, Taylor RM, Wiley JS, Sluyter R: TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes. Biochim Biophys Acta. 2010 Nov;1798(11):2058-66. , *Jin Z, Teramoto N, Hayashi K, Liu YX, Jin G, Oka T, Takahashi K, Yoshino T, Akagi T: CD40 ligand stimulation inhibits the proliferation of mantle cell lymphoma lines. Anticancer Res. 2004 Mar-Apr;24(2B):691-7.
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD39   monoclonal  
• Gene symbol
  ENTPD1
• Short name
  Anti-CD39 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG2b
• Alternative name
  Mouse Monoclonal to CD39
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3363
• Gene
  ENTPD1
• Long gene name
  ectonucleoside triphosphate diphosphohydrolase 1
• Synonyms gene
  • CD39
• Synonyms
  • NTPDase-1
  • ATPDase
  • SPG64
• GenBank acession
  • S73813
• Locus
  10q24.1
• Discovery year
  1994-12-09
• Entrez gene record
  953
• Pubmed identfication
  • 9226376
  • 24482476
• RefSeq identity
  • NM_001776
• Classification
  • Ectonucleoside triphosphate diphosphohydrolase family
  • CD molecules
• VEGA ID
  OTTHUMG00000018818

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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