A slow-releasing, water-soluble hydrogen sulfide (H₂S) donor. Displays vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.
C₁₁H₁₅NO₂PS₂ · C₄H₁₀NO
Is it cell-permeable?
≥95% by HPLC
Is this a salt?
Protect from air and moisture
Maximum time for storage
DMSO (15 mg/ml) or water (30 mg/ml)
For cells, cell lines and tissues in culture till half confluency.