Plasminogen Activator Inhibitor Type 1, Human, Recombinant (PAI 1)
-
Catalog numberMBS637507
-
PricePlease ask
-
Size5x0.05 mg
-
-
Products_typeActive Protein
-
Products_short_name[Plasminogen Activator Inhibitor Type 1]
-
Other_names[plasminogen activator inhibitor 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1]
-
Other_gene_names[SERPINE1; SERPINE1; PAI; PAI1; PAI-1; PLANH1; PAI1; PLANH1; PAI; PAI-1]
-
SpecificityBy uPA activity assay, the recombinant PAI-1 contains a mixture of the active and latent forms, with 45% of active form. The recombinant PAI-1 is able to bind to uPA resulting in a SDS-stable complex.
-
PurityPurified~ 98%, as determined by SDS-PAGE gel electrophoresis.
-
FormSupplied as a liquid in PBS, pH 6.6, 2mM Glutathione, and 0.01% Tween-80
-
Storage_stabilityAliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
-
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
DescriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
SourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolSERPINE1, SERPINB2, SERBP1
-
Short namePlasminogen Activator Inhibitor 1, , Recombinant (PAI 1)
-
TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
HostE Coli
-
SpeciesHuman, Humans
-
Alternative namePlasminogen Activator suppressor classification 1, H. sapiens, Rec. (PAI 1)
-
Alternative techniquerec
-
Gene info
-
Identity
-
Gene
-
Long gene nameserpin family E member 1
-
Synonyms gene
-
Synonyms gene name
- serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1986-01-01
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Serpin peptidase inhibitors
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameserpin family B member 2
-
Synonyms gene
-
Synonyms gene name
- serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
- serpin peptidase inhibitor, clade B (ovalbumin), member 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1989-02-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Serpin peptidase inhibitors
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameSERPINE1 mRNA binding protein 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2005-09-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data