anti-M-CSF Antibody

• Catalog number
  XP-5227
• Price
  Please ask
• Size
  0.1 mg

• Gene info
  Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).
• Gene names
  MCSF, CSF-1Macrophage colony-stimulating factor 1, Lanimostim, CSF-1
• Antibodie s label
  unlabelled serum
• Purity
  Anti-hM-CSF specific antibody was purified by affinity chromatography employing immobilized hM-CSF matrix.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hM-CSF (human M-CSF).
• Immuno application
  ELISA, Western Blot, NELISAut
• Antibody advice
  Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hM-CSF (7.0 ng/mL), a concentration of 0.02 0.03 ug/mL of this antibody is required. ELISA:To detect hM-CSF by direct ELISA (using 100 μL/well antibody solution) a concentration of at least 0.5 ug/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of 0.2 - 0.4 ng/well of recombinant hM-CSF. Sandwich:To detect hM-CSF by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5 - 2.0 ug/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with our Biotinylated Anti-Human M-CSF (XP-5227Bt) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hM-CSF. Western Blot:To detect hM-CSF by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hM-CSF is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
• Keep at
  M-CSF antibody is stable for at least 2 years from date of receipt at -20 grades C. The reconstituted antibody is stable for at least two weeks at 2-8 grades C. Frozen aliquots are stable for at least 6 months when stored at -20 grades C. Avoid repeated freeze-thaw cycles.
• Works with
  Human
• Omim nr
  311033367
• Ncbi nr
  P09603
• Vial with antibody
  Lyophilized
• NCBI GENE nr
  1435
• GENE symbol
  CSF1
• Antigene name
  colony stimulating factor 1 (macrophage)
• Source
  Homo sapiens
• Protein nr
  P09603
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  M-CSF  
• Gene symbol
  CSF1, CPT1B, CSF2, IRAK3, PGAM2, CYP20A1, USP16, CYB5B, H3C14, CSF3
• Short name
  anti-M-CSF Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toM-CSF (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2432
• Gene
  CSF1
• Long gene name
  colony stimulating factor 1
• Synonyms gene name
  • colony stimulating factor 1 (macrophage)
• Synonyms
  • M-CSF
  • MCSF
  • MGC31930
• Synonyms name
  • macrophage colony stimulating factor 1
• GenBank acession
  • BC021117
• Locus
  1p13.3
• Discovery year
  1986-01-01
• Entrez gene record
  1435
• Pubmed identfication
  • 1540160
• RefSeq identity
  • NM_000757
• VEGA ID
  OTTHUMG00000011646

Gene info

• Identity
  HGNC:2329
• Gene
  CPT1B
• Long gene name
  carnitine palmitoyltransferase 1B
• Synonyms gene name
  • carnitine palmitoyltransferase 1B (muscle)
• Synonyms
  • M-CPT1
  • CPT1-M
• Synonyms name
  • carnitine O-palmitoyltransferase 1B
• GenBank acession
  • U62733
• Locus
  22q13.33
• Discovery year
  1996-08-14
• Entrez gene record
  1375
• Pubmed identfication
  • 9070950
• RefSeq identity
  • NM_152246
• VEGA ID
  OTTHUMG00000137390

Gene info

• Identity
  HGNC:2434
• Gene
  CSF2
• Long gene name
  colony stimulating factor 2
• Synonyms gene name
  • colony stimulating factor 2 (granulocyte-macrophage)
• Synonyms
  • GM-CSF
  • GMCSF
• Synonyms name
  • sargramostim
  • molgramostim
  • granulocyte-macrophage colony stimulating factor
• GenBank acession
  • M11734
• Locus
  5q31.1
• Discovery year
  2001-06-22
• Entrez gene record
  1437
• Pubmed identfication
  • 3898082
  • 2999978
• RefSeq identity
  • NM_000758
• VEGA ID
  OTTHUMG00000059637

Gene info

• Identity
  HGNC:17020
• Gene
  IRAK3
• Long gene name
  interleukin 1 receptor associated kinase 3
• Synonyms gene name
  • interleukin-1 receptor-associated kinase 3
• Synonyms
  • IRAK-M
• GenBank acession
  • AF113136
• Locus
  12q14.3
• Discovery year
  2002-07-17
• Entrez gene record
  11213
• Pubmed identfication
  • 10383454
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000169002

Gene info

• Identity
  HGNC:8889
• Gene
  PGAM2
• Long gene name
  phosphoglycerate mutase 2
• Synonyms gene name
  • phosphoglycerate mutase 2 (muscle)
• Synonyms
  • PGAM-M
• Locus
  7p13
• Discovery year
  1989-06-30
• Entrez gene record
  5224
• Classification
  • Phosphoglycerate mutases
  • Bisphosphoglycerate phosphatases
• VEGA ID
  OTTHUMG00000155355

Gene info

• Identity
  HGNC:20576
• Gene
  CYP20A1
• Long gene name
  cytochrome P450 family 20 subfamily A member 1
• Synonyms gene name
  • cytochrome P450, family 20, subfamily A, polypeptide 1
• Synonyms
  • CYP-M
• GenBank acession
  • AK021770
• Locus
  2q33.2
• Discovery year
  2003-03-20
• Entrez gene record
  57404
• RefSeq identity
  • NM_020674
• Classification
  • Cytochrome P450 family 20
• VEGA ID
  OTTHUMG00000132854

Gene info

• Identity
  HGNC:12614
• Gene
  USP16
• Long gene name
  ubiquitin specific peptidase 16
• Synonyms gene name
  • ubiquitin specific protease 16
• Synonyms
  • Ubp-M
• GenBank acession
  • AF126736
• Locus
  21q21
• Discovery year
  1999-07-09
• Pubmed identfication
  • 12838346
• Classification
  • Ubiquitin specific peptidases
• VEGA ID
  OTTHUMG00000078802

Gene info

• Identity
  HGNC:24374
• Gene
  CYB5B
• Long gene name
  cytochrome b5 type B
• Synonyms gene name
  • cytochrome b5 type B (outer mitochondrial membrane)
• Synonyms
  • CYB5-M
• Locus
  16q22.1
• Discovery year
  2006-01-30
• Entrez gene record
  80777
• Pubmed identfication
  • 11867265
  • 14733950
• RefSeq identity
  • NM_030579
• VEGA ID
  OTTHUMG00000133020

Gene info

• Identity
  HGNC:20503
• Gene
  H3C14
• Long gene name
  H3 clustered histone 14
• Synonyms gene
  • H3F2
  • H3FM
  • HIST2H3C
• Synonyms gene name
  • H3 histone family, member M
  • histone 2, H3c
  • histone cluster 2, H3c
  • histone cluster 2 H3 family member c
• Synonyms
  • MGC9629
  • H3/m
  • H3
  • H3.2
  • H3/M
• GenBank acession
  • AF531307
• Locus
  1q21.2
• Discovery year
  2003-02-19
• Entrez gene record
  126961
• Pubmed identfication
  • 12408966
  • 3013246
• RefSeq identity
  • NM_021059
• Classification
  • H3 histones
• VEGA ID
  OTTHUMG00000012190

Gene info

• Identity
  HGNC:2438
• Gene
  CSF3
• Long gene name
  colony stimulating factor 3
• Synonyms gene
  • GCSF
  • G-CSF
  • C17orf33
• Synonyms gene name
  • chromosome 17 open reading frame 33
  • colony stimulating factor 3 (granulocyte)
• Synonyms
  • MGC45931
• Synonyms name
  • granulocyte colony stimulating factor
  • pluripoietin
  • filgrastim
  • lenograstim
• Locus
  17q21.1
• Discovery year
  2001-06-22
• Entrez gene record
  1440
• Pubmed identfication
  • 3499671
  • 3501046
• RefSeq identity
  • NM_172220
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000133247

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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