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Caspase 1 Inhibitor

Caspase 1 Inhibitor is available 5 times from Biovision labs

K151-100 | Caspase-1 Inhibitor Drug Screening Kit (Fluorometric) size: 100 assays | 632.02 USD

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1012-100 | Caspase-1 Inhibitor Z-YVAD-FMK size: 100 µl | 333.56 USD

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1012-20C | Caspase-1 Inhibitor Z-YVAD-FMK size: 20 µl | 333.56 USD

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1012-100 | Caspase-1 Inhibitor Z-YVAD-FMK for cell activation size: 100 µl | 217.69 USD

Catalog number 1012-100
Supplier Biovision
Price 217.69 USD
Size 100 µl
Category Caspase Inhibitor
Supplied with In DMSO (2 mM)
Additional description Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Gene targetCaspase-1 Inhibitor Z-YVAD-FMK for activation
Short name Caspase-1 Inhibitor Z-YVAD-FMK for activation
Technique activation
Alternative name caspase-1 suppressor Z-YVAD-FMK to measure cellular activation
Tissue cell
1. Gene info
Identity 9544
Gene PSMB7
Long gene name proteasome 20S subunit beta 7
Synonyms gene name
  • proteasome (prosome, macropain) subunit, beta type, 7
  • proteasome subunit beta 7
Synonyms
  • Z
Synonyms name
  • proteasome subunit β2
GenBank acession
  • AJ420455
Locus 9q33.3
Discovery year 1995-11-22
Entrez gene record 5695
Pubmed identfication
  • 8811196
RefSeq identity
  • NM_002799
Classification
  • Proteasome
Havana BLAST/BLAT OTTHUMG00000021042
Product images
    #0#.jpegCaspase-1 Inhibitor Z-YVAD-FMK

1012-20C | Caspase-1 Inhibitor Z-YVAD-FMK for cell activation size: 20 µl | 217.69 USD

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Description A synthetic peptide that irreversibly inhibits ICE (interleukin-1β converting enzyme, Ki = 0.76 nM) activity. YVAD is the preferred recognition sequence for ICE/caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Peptide sequence Z-Tyr-Val-Ala-Asp(OMe)-FMK
CAS number N/A
Molecular weight 630.7
Other name Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
Molecular formula C₃₁H₃₉FN₄O₉
Physical appearance Liquid
Is this a salt? No
Is it cell-permeable? Yes
Purification >99% by HPLC
Reconstitute instructions N/A
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 6-12 months
Storage instructions Protect from light and moisture
Alternate Name/Synonyms Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
Appearance Liquid
CAS Number N/A
Molecular Formula C₃₁H₃₉FN₄O₉
Molecular Weight 630.7
Purity >99% by HPLC
Solubility/Reconstitution Instructions N/A
Handling Protect from light and moisture
Tagline Caspase-1 inhibitor
Storage Temp. -20°C
Shipping Conditions gel pack
Shelf Life 6-12 months
MDL Number N/A
PubChem CID 16760349
Kit's description Caspases have been shown to play a crucial role in apoptosis induced by various deleterious and physiologic stimuli. Inhibition of caspases can delay apoptosis, implicating a potential role in drug screening efforts. The Caspase-1 Inhibitor Drug Screening Kit provides an effective means for screening caspase inhibitors using fluorometric methods. The assay utilizes synthetic peptide substrate YVAD-AFC (AFC, 7-amino-4-trifluoromethyl coumarin). Active caspase-1 cleaves the synthetic substrate to release free AFC which can then be quantified by fluorometry. Compounds to be screened can directly be added to the reaction and the level of inhibition of caspase-1 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors.
Highlights • Detection method: FFluorescence (Ex/Em 400/505) • Species reactivity: Mammalian • Kit size: 100 assays • Applications: Effective means for screening caspase inhibitors using fluorometric methods.
Kit's benefits • Simple one-step procedure; takes only 1-1.5 hours • Fast and convenient • Inhibition of caspase-1 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors.
Kit's other name none
Contents • 2X Reaction Buffer • Caspase Substrate YVAD-AFC (1 mM) • DTT (1 M) • Active Caspase-1 (Lyophilized) • Caspase Inhibitor, Z-VAD-FMK (2 mM)
Maximum time can be stored 6-12 months
Species reactivity see datasheet
Applications Detect early/middle stages of apoptosis; differentiate apoptosis from necrosis.
Samples tested Cell samples treated with Caspase inhibitor drugs
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Caspase-1 Inhibitor Z-YVAD-FMK for activation | Technique al
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • Caspase-1
  • Inhibitor
  • Drug
  • Screening
  • Kit
  • Fluorometric
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