RS-504393
-
Catalog numberB2406-5
-
PricePlease ask
-
Size5 mg
-
-
Alternative_name6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
-
DescriptionRS-504393 is a selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC₅₀ = 330 nM) and ischemia-reperfusion injury in kidneys.
-
CAS Number300816-15-3
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₅H₂₇N₃O₃
-
Molecular Weight417.5
-
Cell PermeableTrue
-
Purity≥98% by HPLC
-
SolubilitiesDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
-
HandlingDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
-
Tag LineA selective CCR2 chemokine receptor antagonist
-
Storage Condition-20ºC
-
Shipping ConditionGel Pack
-
Shelf Life36 months
-
PubChem CID9953769
-
SMILESCC1=CC2=C(C=C1)NC(=O)OC23CCN(CC3)CCC4=C(OC(=N4)C5=CC=CC=C5)C
-
InChiInChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)
-
InChi KeyODNICNWASXKNNQ-UHFFFAOYSA-N
-
MSDS AvailableTrue
-
Gene target
-
Gene symbolRS1, REG1CP, RHBDF1, PTENP1, PITX2
-
Short nameRS-504393
-
Alternative nameRS-504393
-
Gene info
-
Identity
-
Gene
-
Long gene nameretinoschisin 1
-
Synonyms gene
-
Synonyms gene name
- retinoschisis (X-linked, juvenile) 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameregenerating family member 1 gamma, pseudogene
-
Synonyms gene
-
Synonyms gene name
- rat regenerating islet-derived-like, human homolog (pancreatic stone protein-like, pancreatic thread protein-like)
- regenerating islet-derived-like, pancreatic stone protein-like, pancreatic thread protein-like (rat)
- regenerating islet-derived 1 pseudogene
-
Synonyms
-
Locus
-
Discovery year1993-07-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namerhomboid 5 homolog 1
-
Synonyms gene
-
Synonyms gene name
- chromosome 16 open reading frame 8
- rhomboid family 1 (Drosophila)
- rhomboid 5 homolog 1 (Drosophila)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-04-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Rhomboid family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namephosphatase and tensin homolog pseudogene 1
-
Synonyms gene name
- phosphatase and tensin homolog pseudogene 1 (functional)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1999-09-09
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namepaired like homeodomain 2
-
Synonyms gene
-
Synonyms gene name
- paired-like homeodomain transcription factor 2
- paired-like homeodomain 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1992-10-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- PRD class homeoboxes and pseudogenes
-
VEGA ID