RS-504393

  • Catalog number
    B2406-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
  • Description
    RS-504393 is a selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC₅₀ = 330 nM) and ischemia-reperfusion injury in kidneys.
  • CAS Number
    300816-15-3
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₅H₂₇N₃O₃
  • Molecular Weight
    417.5
  • Cell Permeable
    True
  • Purity
    ≥98% by HPLC
  • Solubilities
    Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
  • Handling
    Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
  • Tag Line
    A selective CCR2 chemokine receptor antagonist
  • Storage Condition
    -20ºC
  • Shipping Condition
    Gel Pack
  • Shelf Life
    36 months
  • PubChem CID
    9953769
  • SMILES
    CC1=CC2=C(C=C1)NC(=O)OC23CCN(CC3)CCC4=C(OC(=N4)C5=CC=CC=C5)C
  • InChi
    InChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)
  • InChi Key
    ODNICNWASXKNNQ-UHFFFAOYSA-N
  • MSDS Available
    True
  • Gene target
  • Gene symbol
    RS1, REG1CP, RHBDF1, PTENP1, PITX2
  • Short name
    RS-504393
  • Alternative name
    RS-504393
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    regenerating family member 1 gamma, pseudogene
  • Synonyms gene
  • Synonyms gene name
    • rat regenerating islet-derived-like, human homolog (pancreatic stone protein-like, pancreatic thread protein-like)
    • regenerating islet-derived-like, pancreatic stone protein-like, pancreatic thread protein-like (rat)
    • regenerating islet-derived 1 pseudogene
  • Synonyms
  • Locus
  • Discovery year
    1993-07-12
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • VEGA ID
Gene info
Gene info
Gene info
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