ABCG1 Antibody (Center)

• Catalog number
  6705-100
• Price
  Please ask
• Size
  100 μl

• Antibody Target
  ABCG1
• Target Alternative Name
  ABCG1; ABC8; WHT1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  This ABCG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-387 amino acids from the central region of human ABCG1.
• Accession
  P45844
• Gene Id
  ABCG1
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  100 µl of antibody in PBS with 0.09% (W/V) sodium azide
• Purification
  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Application
  Western blot, IHC, FACS
• Positive Control
  Western blot: 293 cell lysate, IHC: human hepatocarcinoma, FACS: HepG2 cells
• Application And Usages
  Western blot: ~1:1000, FACS: ~1:10–1:50, IHC: ~1:50-1:100.
• Description
  ABCG1 (ATP-binding cassette sub-family G member 1), a transporter protein primarily involved in macrophage lipid homeostasis, localizes to intracellular compartments associated with ER /Golgi membranes, and its expression is highest in macrophage-rich tissue such as spleen, lung, and thymus as well as in brain. ABCG1 form heterodimers with heterologous ABCG partners and functional heterodimerization with ABCG4 has been of great interest because brain cells, mainly neurons and astrocytes, depict high expression of both transporters. ABCG1 is involved in the export of a variety of lipids (in conjunction with ABCA1) including cholesterol and phospholipids from macrophages to HDL. Macrophage lipid export is the first step in the reverse cholesterol transport pathway that exports cholesterol from peripheral cells to circulating lipoproteins for eventual excretion via liver. Cholesterol export to lipoprotein acceptors is compromised in macrophage foam cells, one of the early hallmarks of atherosclerosis. Moreover, ABCG1 plays role in T cells/inflammation, brain lipid homeostasis and its expression increases in macrophages of Tangier disease patients.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ABCG1   Center  
• Gene symbol
  ABCG1
• Short name
  ABCG1 Antibody (Center)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  adenosine triphosphate-binding cassette, sub-family G (WHITE), member 1 (antibody to-) (central)
• Alternative technique
  antibodies
• Alternative to gene target
  ATP-binding cassette, sub-family G (WHITE), member 1, ABC8 and WHITE1, ABCG1 and IDBG-4231 and ENSG00000160179 and 9619, protein dimerization activity, Cell surfaces, Abcg1 and IDBG-163644 and ENSMUSG00000024030 and 11307, BT.29337 and IDBG-639382 and ENSBTAG00000021272 and 510745

Gene info

• Identity
  HGNC:73
• Gene
  ABCG1
• Long gene name
  ATP binding cassette subfamily G member 1
• Synonyms gene name
  • ATP-binding cassette, sub-family G (WHITE), member 1
• Synonyms
  • ABC8
• Synonyms name
  • ATP-binding cassette transporter 8
• GenBank acession
  • U34919
• Locus
  21q22.3
• Discovery year
  1999-10-26
• Entrez gene record
  9619
• Pubmed identfication
  • 8659545
  • 16870176
• RefSeq identity
  • NM_207174
• Classification
  • ATP binding cassette subfamily G
• VEGA ID
  OTTHUMG00000086791

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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